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[Mathematical study of the sensitivity curves of Escherichia coli exposed to polymyxins].

Abstract : The time killing curves of five strains of Escherichia coli (ATCC 25922, ATCC 29194, CIP 54125, CIP 54127, CIP 54117 (K 12)) exposed to five concentrations of polymyxin B are similar: latency phasis, two decreasing phasis and for the low polymyxin B concentrations growth phasis. In our experimental conditions, the Mg(+)+ and Ca(+)+ concentrations of the medium (Mueller-Hinton; medium A: Ca(+)+ = 9 mg/l, Mg(+)+ = 0.5 mg/l; medium B: Ca(+)+ = 35 mg/l, Mg(+)+ = 15.5 mg/l; medium C: Ca(+)+ = 60 mg/l, Mg(+)+ = 20 mg/l) have no time effect upon the killing curves. A decreasing biexponential model can be fitted to the data. Such a model is compatible with interaction between antibiotic and bacterium and can be formalized accorrding to the equation: T + ATB K1 in equilibrium of K2 T* - ATB K3----ATB + dead with ATB: Polymyxine B in excess, T: target bacterium and T*: modification target bacterium.
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https://hal.archives-ouvertes.fr/hal-02332651
Contributor : Jean-Pierre Flandrois <>
Submitted on : Thursday, October 24, 2019 - 9:53:56 PM
Last modification on : Wednesday, July 21, 2021 - 3:10:02 PM

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  • HAL Id : hal-02332651, version 1
  • PUBMED : 2164182

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M. Peyret, G. Carret, C. Carré, G. Fardel, Jean-Pierre Flandrois. [Mathematical study of the sensitivity curves of Escherichia coli exposed to polymyxins].. Pathologie Biologie, Elsevier Masson, 1990, 38 (5), pp.441-5. ⟨hal-02332651⟩

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