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[Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B].

Abstract : The time-killing curves of three strains of Pseudomonas aeruginosa (PA01, ATCC10145 and ATCC27853) exposed to five concentrations of polymyxin B comprised: a latency phases, one or two decreasing phases and for the low polymyxin B concentrations a growth phasis. The five antibiotic concentrations were chosen to have a weak bactericidal effect such that decreasing exponential or biexponential models can be fitted to the data. In our experimental conditions, increasing Ca++ and Mg++ concentrations in the medium (Mueller-Hinton) reduced the bactericidal effect and increased the growth phases. Increasing inoculum (10(5) to 10(7) CFU/ml) decreased the bactericidal effect observed with polymyxin B.
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Contributor : Jean-Pierre Flandrois Connect in order to contact the contributor
Submitted on : Thursday, October 24, 2019 - 9:49:18 PM
Last modification on : Wednesday, July 21, 2021 - 3:10:02 PM


  • HAL Id : hal-02332645, version 1
  • PUBMED : 1909018



M. Peyret, Jean-Pierre Flandrois, G. Fardel. [Time-killing curves of Pseudomonas aeruginosa strains exposed to polymyxin B].. Pathologie Biologie, Elsevier Masson, 1991, 39 (5), pp.446-50. ⟨hal-02332645⟩



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