An Organocatalytic Two-atom Ring Expansion Approach to Optically Active Glutarimides

Yun-Long Wei (1) , Yajun Ren (1) , Damien Mailhol (1) , Michel Rajzmann (1) , Jean Rodriguez (1) , Yoann Coquerel (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

An original two-step organocatalytic syn- thesis of optically active glutarimides from 2- oxocyclobutane carboxamides is described featuring an isothiourea-catalyzed two-atom ring-expansive rearrangement.

Mots clés: Organocatalysis; Ring expansion; Rearrangement; Nitrogen heterocycles; Strained molecules

Domaines: Chimie organique; Catalyse

Yun-Long Wei, Yajun Ren, Damien Mailhol, Michel Rajzmann, Jean Rodriguez, et al.. An Organocatalytic Two-atom Ring Expansion Approach to Optically Active Glutarimides. Advanced Synthesis and Catalysis, 2019, 361, pp.2992-3001. ⟨10.1002/adsc.201900159⟩. ⟨hal-02331641⟩