From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy

E. Lefebvre (1) , I. Lequeux (2) , C. Vighetto (1) , I. Fromantin (3) , P. Thébault (2) , D. Seyer (1) , J. Picard , L. Teot (4) , S. Meaume (5) , M. Freitas (3, 1) , S. Neffati (3) , L. El Guermah (4) , S. Pellissier (6) , S. Giraudier , T. Jouenne (2) , V.L. Garde (1)

1 ERRMECe - Equipe de recherche sur les relations matrice extracellulaire-cellules
2 PBS - Polymères Biopolymères Surfaces
3 Centre de recherche de l'Institut Curie [Paris]
4 CHU Montpellier
5 CHU Rothschild [AP-HP]
6 Institut Curie [Paris]

The PANSaBIO project aims to evaluate the prevalence of biofilms on a large panel of chronic wounds (more than 100 samples) and relate its presence to the type and history of the wound and its microbiology. A large file computing all the data is under construction. Moreover, several strategies to prepare an innovative anti-biofilm dressing have been developed. On one hand, antimicrobial peptides were grafted to gelatin; the modified protein can be used to prepare an active dressing. Second, various antiseptics were entrapped in a gelatin gel. An adaptation was necessary to obtain the convenient mechanical properties of the gel. Then this preparation was turned to a dressing. A first generation of dressings efficient against biofilms of Pseudomonas aeruginosa and Staphylococus aureus is available today.

Domaines: Chimie

E. Lefebvre, I. Lequeux, C. Vighetto, I. Fromantin, P. Thébault, et al.. From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy. Innovation and Research in BioMedical engineering, 2014, 35 (2), pp.77-81. ⟨10.1016/j.irbm.2014.02.003⟩. ⟨hal-02323048⟩