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The Inside Out of Lentiviral Vectors

Abstract : Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
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https://hal.archives-ouvertes.fr/hal-02322800
Contributor : Andrea Cimarelli <>
Submitted on : Wednesday, May 12, 2021 - 12:57:14 PM
Last modification on : Friday, June 11, 2021 - 4:14:02 PM

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Stéphanie Durand, Andrea Cimarelli. The Inside Out of Lentiviral Vectors. Viruses, MDPI, 2011, 3 (2), pp.132-159. ⟨10.3390/v3020132⟩. ⟨hal-02322800⟩

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