Bacterial Adherence to Plant and Animal Surfaces Via Adhesin-Lipid Interactions
Résumé
The plasma membrane acts as one of the first lines of defense by establishing a
physical barrier against microbes. Nevertheless, bacteria have developed a range
of strategies to invade the host tissues efficiently. In this chapter, we focus on this
understudied area and describe how bacteria target or redirect host membrane lipids. Domains enriched in sterols and sphingolipids, denominated membrane
rafts, in particular, have been reported to be exploited by numerous bacterial
pathogens. We will first describe the different strategies employed by bacteria to
specifically target the PM via membrane rafts and non-raft counterpart domains;
and secondly, we illustrate how development of biomimetic membranes has
identified bacterial mechanisms of interaction.
Domaines
Microbiologie et Parasitologie
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