Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening, Clinical infectious diseases, vol.46, issue.2, pp.165-171, 2008. ,
New medicines to improve control and contribute to the eradication of malaria, Nat Rev Drug Discov, vol.8, issue.11, pp.879-91, 2009. ,
The global pipeline of new medicines for the control and elimination of malaria, Malaria Journal, vol.11, p.316, 2012. ,
Synthesis of new 1,2,4-trioxanes and their antimalarial activity, Helv. Chim. Acta, vol.71, pp.1805-1812, 1988. ,
Synthetic peroxides as potent antimalarials. News and views, Current Topics in Medicinal Chemistry, vol.12, pp.373-399, 2012. ,
Synthesis and antimalarial activity of trioxaquine derivatives, Chem. Eur. J, vol.10, pp.1625-1636, 2004. ,
Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice, J. Med. Chem, vol.49, pp.2794-2803, 2006. ,
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins, ChemBioChem, vol.6, pp.2048-2054, 2005. ,
Identification of an antimalarial synthetic trioxolane drug development candidate, Nature, vol.430, pp.900-904, 2004. ,
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria, Proc. Natl. Acad. Sci. USA, vol.108, pp.4400-4405, 2011. ,
Synthesis of five and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products, Belstein J. Org. Chem, vol.10, pp.34-114, 2014. ,
Antimalarial cyclic peroxy ketals, J. Med. Chem, vol.41, pp.2164-2167, 1998. ,
RO-42-1611 (arteflene), a new effective antimalarial -chemical-structure and biological-activity, Trop. Med. Parasitol, vol.45, pp.261-265, 1994. ,
A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides, J. Med. Chem, vol.46, pp.2516-2533, 2003. ,
Design and synthesis of endoperoxide antimalarial prodrug models, Angew. Chem. Int. Ed, vol.43, pp.4193-4197, 2004. ,
Substituted organic peroxides: synthetic strategies for a biologically important class of gemdihydroperoxide and perketal derivatives, Org. Biomol. Chem, vol.5, pp.3895-3908, 2007. ,
Synthesis and reactions of beta-hydroxyhydroperoxides, J. Chem. Soc., Chem. Commun, pp.508-509, 1976. ,
Macrocycles -synthesis and thermal-decomposition of some disubstituted dicyclohexylidene diperoxides, Synthesis, pp.159-161, 1975. ,
Dispiro-1,2,4,5-tetraoxanes -a new class of antimalarial peroxides, J. Med. Chem, vol.35, pp.3023-3027, 1992. ,
Spiro-and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides, J. Med. Chem, vol.50, pp.5840-5847, 2007. ,
A facile access to bridged 1,2,4-trioxanes, Tetrahedron, vol.62, pp.11627-11634, 2006. ,
Facile construction of 6-carbomethoxymethyl-3-methoxy-1,2-dioxane, a core structure of spongean anti-malarial peroxides, Tetrahedron Lett, vol.42, pp.7281-7285, 2001. ,
New readily accessible peroxides with high anti-malarial potency, Bioorg. Med. Chem. Lett, vol.12, pp.69-72, 2002. ,
Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: Mechanistic comparators for artemisinin in the context of reaction pathways with iron(II), J. Org. Chem, vol.70, pp.5103-5110, 2005. ,
A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity, Tetrahedron Lett, vol.39, pp.6065-6068, 1998. ,
Intramolecular reactions of hydroperoxides and oxetanes: Stereoselective synthesis of 1,2-dioxolanes and 1,2-dioxanes, Org. Lett, vol.7, pp.4333-4335, 2005. ,
Synthesis of 1,2,4-trioxanes and 1,2,4-trioxepanes by N-halogenosuccinimide-mediated cyclisations of unsaturated hydroperoxyacetals, J. Chem. Soc., Perkin Trans, vol.1, pp.5-10, 1997. ,
Dispiro-1,2,4,5-tetraoxanes via ozonolysis of cycloalkanone O-methyl oximes: A comparison with the peroxidation of cycloalkanones in acetonitrile-sulfuric acid media, J. Org. Chem, vol.63, pp.8582-8585, 1998. ,
Identification of an antimalarial synthetic trioxolane drug development candidate, Nature, vol.430, pp.900-904, 2004. ,
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria, Proc Natl Acad Sci U.S.A, vol.108, issue.11, pp.4400-4405, 2011. ,
Preparation of beta-hydroxyhydroperoxides by photooxygenation of allylic alcohols and their elaboration into 1,2,4-trioxanes, Tetrahedron Lett, vol.31, pp.6901-6902, 1990. ,
A halogenocyclization route to 1,2,4-trioxanes, Tetrahedron Lett, vol.34, pp.6643-6646, 1993. ,
Synthesis of 1,2,4-trioxanes via intramolecular oxymercuriation, J. Chem. Soc., Chem. Commun, pp.947-948, 1991. ,
Synthesis, structure, and antimalarial activity of some enantiomerically pure, cis-fused cyclopenteno-1,2,4-trioxanes, Helv. Chim. Acta, vol.78, pp.647-662, 1995. ,
Preparation and antimalarial activities of "trioxaquines, vol.4, pp.281-283, 2000. ,
Synthesis, structure, and antimalarial activity of tricyclic 1,2,4-trioxanes related to artemisinin, Helv. Chim. Acta, vol.76, pp.2775-2788, 1993. ,
Antimalarial sulfone trioxanes, Tetrahedron Lett, vol.39, pp.2273-2276, 1998. ,
): a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes, Tetrahedron Lett, vol.44, issue.2, pp.8135-8138, 2003. ,
Synthesis and in vitro antimalarial activity of sulfone endoperoxides, Bioorg. Med. Chem. Lett, vol.8, pp.903-908, 1998. ,
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore, Org. Lett, vol.6, pp.3035-3038, 2004. ,
Antimalarial cyclic peroxy ketals, J. Med. Chem, vol.41, pp.2164-2167, 1998. ,
Total synthesis of (+/-)-Chondrillin, (+/-)-Plakorin, and related peroxy ketals -development of a general-route to 3,6-dihydro-1,2-dioxin-3-ols, J. Am. Chem. Soc, vol.114, pp.1790-1800, 1992. ,
Synthesis of pentasubstituted 3-hydroxy-1,2-dioxolanes, J. Org. Chem, vol.57, pp.393-395, 1992. ,
Antimalarial peroxides: advances in drug discovery and design, MedChemComm, vol.3, pp.281-297, 2012. ,
Bioactive acylphloroglucinol derivatives from Eucalyptus species, Phytochemistry, vol.41, pp.7-22, 1996. ,
Plant-growth regulators in Eucalyptus-grandis .4. Synthetic approaches to G-regulator analogs, Aust. J. Chem, vol.35, pp.1411-1419, 1982. ,
Bicyclic peroxydes in the G factors series: synthesis and electrochemical studies, Tetrahedron Lett, vol.42, pp.2465-2468, 2001. ,
A combined spin trapping/EPR/mass spectrometry approach to study the formation of a cyclic peroxide by dienolic precursor autoxidation, Org. Biomol. Chem, vol.8, pp.1361-1367, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-01460310
André-Barrès, C. Synthesis and electrochemical studies of new antimalarial endoperoxides, Eur. J. Org. Chem, vol.17, pp.3335-3343, 2003. ,
André-Barrès, C. Crucial role of the peroxyketal function for antimalarial activity in the G-factor series, Bioorg. Med. Chem. Lett, vol.14, pp.1433-1436, 2004. ,
Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies, Org. Biomol. Chem, vol.3, pp.1612-1614, 2005. ,
Artemisinin (qinghaosu): The role of intracellular hemin in its mechanism of antimalarial action, Mol. Biochem. Parasitol, vol.49, pp.181-189, 1991. ,
Hemin-catalyzed decomposition of artemisinin (qinghaosu), Biochem. Pharmacol, vol.43, pp.1805-1809, 1992. ,
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu), Antimicrob. Agents Chemother, vol.37, pp.1108-1114, 1993. ,
Electrochemical reduction of G3-factor endoperoxide and its methyl ether: Evidence for a competition between concerted and stepwise dissociative electron transfer, Chem. Eur. J, vol.13, pp.1174-1179, 2007. ,
First computational evidence of a competitive stepwise and concerted mechanism for the reduction of antimalarial endoperoxides, J. Phys. Chem. B, vol.114, pp.9848-9853, 2010. ,
Fe(II)-induced reduction of labelled endoperoxides. NMR degradation studies on G3 factor and its methyl ether, J. Org. Chem, vol.70, pp.6921-6924, 2005. ,
The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?, Trends in parasitology, vol.18, pp.441-444, 2002. ,
New amino endoperoxides belonging to the antimalarial G-factors series, Eur. J. Org. Chem, vol.19, pp.3095-3101, 2007. ,
Synthesis of antimalarial G-factors endoperoxides: relevant evidence of the formation of a biradical during the autoxidation step, Tetrahedron, vol.64, pp.9216-9224, 2008. ,
Mechanism-based design of parasitetargeted artemisinin derivatives: Synthesis and antimalarial activity of new diamine containing analogues, J. Med. Chem, vol.45, pp.1052-1063, 2002. ,
André-Barrès, C. ?-Spiro endoperoxides: synthesis and evaluation of their antimalarial activities, Tetrahedron, vol.65, pp.7372-7379, 2009. ,
Synthesis and Antimalarial Properties of Streptocyanine Dyes, ChemMedChem, vol.4, pp.1327-1332, 2009. ,
Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes, Org. Biomol. Chem, vol.9, pp.7400-7410, 2011. ,
Ciprofloxacin and Malaria, The Lancet, vol.331, pp.1231-1232, 1988. ,
Enhancement of the Antimalarial Activity of Ciprofloxacin using a Double Prodrug/Bioorganometallic Approach, J. Med. Chem, vol.52, pp.7954-7957, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00641967
Plastid in human parasites, Nature, vol.381, pp.482-482, 1996. ,
, , 2008.
Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies, MedChemComm, vol.2, pp.430-435, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00641730
, Quinolone-3-Diarylethers: A New Class of Antimalarial Drug, pp.177-214, 2013.