Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants

Lucie Valero (1) , Khair Alhareth (1) , Sophie Gil (2) , Christelle Simasotchi , Caroline Roques (1) , Daniel Scherman (3) , Nathalie Mignet (1) , Thierry Fournier , Karine Andrieux (1)

1 UTCBS - UM 4 (UMR 8258 / U1022) - Unité de Technologies Chimiques et Biologiques pour la Santé
2 U1139 - Physiopathologie et Pharmacotoxicologie Placentaire Humaine
3 UPCGI - UMR 8151 / UMR_S 1022 - Unité de pharmacologie chimique et génétique et d'imagerie

Domaines: Pharmacie galénique

Lucie Valero, Khair Alhareth, Sophie Gil, Christelle Simasotchi, Caroline Roques, et al.. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants. International Journal of Pharmaceutics, 2017, 532 (2), pp.729-737. ⟨10.1016/j.ijpharm.2017.07.076⟩. ⟨hal-02319716⟩