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POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project

Jean Bousquet 1, 2 Josep M. Anto Isabella Annesi-Maesano 3 Toni Dedeu Eve Dupas Jean-Louis Pépin 4 Landry Stephane Zeng Eyindanga Sylvie Arnavielhe Julia Ayache Xavier Basagana 5, 6 Samuel Benveniste 7 Nuria Calves Venturos Hing Kin Chan Mehdi Cheraitia Yves Dauvilliers 8, 9 Judith Garcia-Aymerich 6 Ingrid Jullian-Desayes 10 Chitra Dinesh Daniel Laune Jade Lu Dac Ismael Nujurally Giovanni Pau 11, 12 Robert Picard Xavier Rodo 13 Renaud Tamisier 14 Michael Bewick Nils E. Billo Wienczyslawa Czarlewski Joao Fonseca Ludger Klimek Oliver Pfaar Jean-Marc Bourez 
Abstract : Allergic rhinitis (AR) is impacted by allergens and air pollution but interactions between air pollution, sleep and allergic diseases are insufficiently understood. POLLAR (Impact of air POLLution on sleep, Asthma and Rhinitis) is a project of the European Institute of Innovation and Technology (EIT Health). It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the Allergy Diary, iOS and Android, 17,000 users, TLR8). The Allergy Diary will be combined with a new tool allowing queries on allergen, pollen (TLR2), sleep quality and disorders (TRL2) as well as existing longitudinal and geolocalized pollution data. Machine learning will be used to assess the relationship between air pollution, sleep and AR comparing polluted and non-polluted areas in 6 EU countries. Data generated in 2018 will be confirmed in 2019 and extended by the individual prospective assessment of pollution (portable sensor, TLR7) in AR. Sleep apnea patients will be used as a demonstrator of sleep disorder that can be modulated in terms of symptoms and severity by air pollution and AR. The geographic information system GIS will map the results. Consequences on quality of life (EQ-5D), asthma, school, work and sleep will be monitored and disseminated towards the population. The impacts of POLLAR will be (1) to propose novel care pathways integrating pollution, sleep and patients' literacy, (2) to study sleep consequences of pollution and its impact on frequent chronic diseases, (3) to improve work productivity, (4) to propose the basis for a sentinel network at the EU level for pollution and allergy, (5) to assess the societal implications of the interaction. MASK paper N°32.
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Jean Bousquet, Josep M. Anto, Isabella Annesi-Maesano, Toni Dedeu, Eve Dupas, et al.. POLLAR: Impact of air POLLution on Asthma and Rhinitis; a European Institute of Innovation and Technology Health (EIT Health) project. Clinical and Translational Allergy, BioMed Central, 2018, 8, pp.36. ⟨10.1186/s13601-018-0221-z⟩. ⟨hal-02316525⟩



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