Evolution of the Saupe order parameters of enantiomers from a racemic to a non-racemic liquid crystal solvent: an original light on the absolute configuration determination problem
Résumé
Chiral liquid crystals used as solvents have been shown to be very powerful in giving separate nuclear magnetic
resonance (NMR) signals for enantiomers. However, a fundamental problem remains: how to attribute absolute
configurations to the various NMR responses? In this paper it is demonstrated that the absolute configuration
problem could be solved in predicting the sign of the rotation of the principal axis system of the Saupe matrix in the
molecular frame when going from an achiral (racemic) to a chiral anisotropic solvent.