Enantiomeric analysis using natural abundance deuterium 3D NMR spectroscopy in polypeptide chiral oriented media

Abstract : The use of natural abundance deuterium (NAD) three-dimensional (3D) NMR experiment in chiral liquid crystals (CLC) is reported and discussed. This homonuclear autocorrelation 3D experiment allows assign-ing deuterium signals of weakly aligned molecules at natural isotopic abundance. It provides an efficient strategy for identifying the spectral enantio-discriminations on NAD spectra. We demonstrate that NAD 3D NMR is feasible within reasonable experimental times (14 h) using the 3D Quadrupole Double-Quan-tum NMR sequence [O. Lafon, P. Lesot, Chem. Phys. Lett. 404 (2005) 90] and a 14.1 T NMR spectrometer equipped with a selective 5 mm deuterium NMR cryoprobe. The analytical potentialities of this technique are illustrated in the case of (±)-but-2-yn-1-ol dissolved in poly-c-benzyl-L-glutamate/CHCl3 mesophase.
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Submitted on : Thursday, October 10, 2019 - 3:49:05 PM
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Philippe Lesot, Olivier Lafon. Enantiomeric analysis using natural abundance deuterium 3D NMR spectroscopy in polypeptide chiral oriented media. Chemical Physics Letters, Elsevier, 2008, 458 (1-3), pp.219-222. ⟨10.1016/j.cplett.2008.04.065⟩. ⟨hal-02310970⟩

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