Routine Use of Natural Abundance Deuterium NMR in a Polypeptidic Chiral Oriented Solvent for the Determination of the Enantiomeric Composition of Chiral Building Blocks

Arnaud Parenty (1) , Jean-Marc Campagne (1) , Christie Aroulanda (2) , Philippe Lesot (2)

1 ICSN - Institut de Chimie des Substances Naturelles
2 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay

Natural abundance deuterium 2D NMR spectroscopy in chiral liquid crystal was successfully used to efficiently analyze the enantiomeric composition of organic chiral building blocks involved in the syntheses of natural and synthetic bioactive products. The results reported here emphasize the high potential of this analytical strategy and prove its applicability for routinely determining enantiomeric excesses.

Mots clés: NAD; Deuterium; NMR; QUOSY; Chiral Building Block; Chiral liquid crystal; PBLG

Domaines: Chimie organique; Chimie analytique

Arnaud Parenty, Jean-Marc Campagne, Christie Aroulanda, Philippe Lesot. Routine Use of Natural Abundance Deuterium NMR in a Polypeptidic Chiral Oriented Solvent for the Determination of the Enantiomeric Composition of Chiral Building Blocks. Organic Letters, 2002, 4 (10), pp.1663-1666. ⟨10.1021/ol020038b⟩. ⟨hal-00165644⟩