Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation

Thomas Wesch (1, 2) , Anaïs Brehier (1, 2) , Frédéric Leroux (3) , Francoise Colobert-Leuenberger (3)

1 Substances naturelles/chimie moléculaire
2 LCM - Laboratoire de chimie moléculaire
3 LIMA - Laboratoire d'innovation moléculaire et applications

Efficient access to dibenzothiophene-S-oxides, e.g., I, from differently substituted 2-bromo-diarylsulfinyl moieties using ligandless Pd(OAc)2 as the catalyst and KOAc as the base in dimethylacetamide at 130 °C is reported. Various dibenzothiophene-S-oxides were obtained in excellent yields.

Domaines: Chimie organique

Thomas Wesch, Anaïs Brehier, Frédéric Leroux, Francoise Colobert-Leuenberger. Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation. Organic Letters, 2013, 15 (10), pp.2490-2493. ⟨10.1021/ol400966q⟩. ⟨hal-02304107⟩