A concise atroposelective formal synthesis of (-)-steganone
Résumé
The atroposelective formal synthesis of (-)-steganone, a parent member of Steganotaenia araliacea dibenzocyclooctadiene lignan lactones, was reported. The synthesis features an atropo-diastereoselective biaryl Suzuki-Miyaura cross-coupling with ≤99% de using an enantiopure and efficiently converted β-hydroxy sulfoxide deriv. as chiral auxiliary.