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Article Dans Une Revue Brain Topography: a Journal of Cerebral Function and Dynamics Année : 2020

Attenuation and delay of remote potentials evoked by direct electrical stimulation during brain surgery

Résumé

Background: Direct electrical stimulation (DES) is used to perform functional brain mapping during awake surgery but its electrophysiological effects remain by far unknown. Hypothesis: DES may be coupled with the measurement of Evoked Potentials (EPs) to study the conductive and integrative properties of activated neural ensembles and probe the spatiotemporal dynamics of short- and long- range networks. Methods: We recorded ECoG signals on two patients undergoing awake brain surgery and measured EPs on functional sites after cortical stimulations, using combinations of stimulation parameters. Results: EPs were similar in shape but delayed in time and attenuated in amplitude when elicited from a different gyrus or remotely from the recording site. We were able to trigger remote EPs using low stimulation intensities. Conclusion: We propose different activation and electrophysiological propagation mechanisms following DES based on activated neural elements.
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Dates et versions

hal-02301730 , version 1 (30-09-2019)

Identifiants

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Anthony Boyer, Hugues Duffau, Emmanuel Mandonnet, Marion Vincent, Sofiane Ramdani, et al.. Attenuation and delay of remote potentials evoked by direct electrical stimulation during brain surgery. Brain Topography: a Journal of Cerebral Function and Dynamics, 2020, 33 (1), pp.143-148. ⟨10.1007/s10548-019-00732-w⟩. ⟨hal-02301730⟩
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