Attenuation and delay of remote potentials evoked by direct electrical stimulation during brain surgery

Abstract : Background: Direct electrical stimulation (DES) is used to perform functional brain mapping during awake surgery but its electrophysiological effects remain by far unknown. Hypothesis: DES may be coupled with the measurement of Evoked Potentials (EPs) to study the conductive and integrative properties of activated neural ensembles and probe the spatiotemporal dynamics of short- and long- range networks. Methods: We recorded ECoG signals on two patients undergoing awake brain surgery and measured EPs on functional sites after cortical stimulations, using combinations of stimulation parameters. Results: EPs were similar in shape but delayed in time and attenuated in amplitude when elicited from a different gyrus or remotely from the recording site. We were able to trigger remote EPs using low stimulation intensities. Conclusion: We propose different activation and electrophysiological propagation mechanisms following DES based on activated neural elements.
Complete list of metadatas

Cited literature [16 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02301730
Contributor : Anthony Boyer <>
Submitted on : Monday, September 30, 2019 - 4:20:52 PM
Last modification on : Wednesday, October 2, 2019 - 1:22:48 AM

Files

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2020-03-26

Please log in to resquest access to the document

Identifiers

Citation

Anthony Boyer, Hugues Duffau, Emmanuel Mandonnet, Marion Vincent, Sofiane Ramdani, et al.. Attenuation and delay of remote potentials evoked by direct electrical stimulation during brain surgery. Brain Topography: a Journal of Cerebral Function and Dynamics, Springer Verlag, In press, ⟨10.1007/s10548-019-00732-w⟩. ⟨hal-02301730⟩

Share

Metrics

Record views

52