Skip to Main content Skip to Navigation
Journal articles

Gene tree reconciliation including transfers with replacement is NP-hard and FPT

Damir Hasic 1 Eric Tannier 2 
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Phylogenetic trees illustrate the evolutionary history of genes and species. Although genes evolve along with the species they belong to, a species tree and gene tree are often not identical. The reasons for this are the evolutionary events at the gene level, like duplication or transfer. These differences are handled by phylogenetic reconciliation, which formally is a mapping between a gene tree nodes and a species tree nodes and branches. We investigate models of reconciliation with gene transfers replacing existing genes, which is a biologically important event, but has never been included in the reconciliation models. The problem is close to the dated version of the classical subtree prune and regraft (SPR) distance problem, where a pruned subtree has to be regrafted only on a branch closer to the root. We prove that the reconciliation problem including transfer with replacement is NP-hard, and that, if speciations and transfers with replacement are the only allowed evolutionary events, it is fixed-parameter tractable with respect to the reconciliation’s weight. We prove that the results extend to the dated SPR problem.
Document type :
Journal articles
Complete list of metadata
Contributor : Eric Tannier Connect in order to contact the contributor
Submitted on : Monday, September 30, 2019 - 2:33:33 PM
Last modification on : Sunday, September 25, 2022 - 3:55:44 AM

Links full text



Damir Hasic, Eric Tannier. Gene tree reconciliation including transfers with replacement is NP-hard and FPT. Journal of Combinatorial Optimization, Springer Verlag, 2019, 38 (2), pp.502-544. ⟨10.1007/s10878-019-00396-z⟩. ⟨hal-02301454⟩



Record views