Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2019

Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin

Gino Agbota
  • Fonction : Auteur
Katja Polman
  • Fonction : Auteur
Frank T. Wieringa
  • Fonction : Auteur
Maiza Campos-Ponce
  • Fonction : Auteur
Manfred Accrombessi
  • Fonction : Auteur
Emmanuel Yovo
  • Fonction : Auteur
Clémentine Roucher
  • Fonction : Auteur
Sem Ezinmègnon
  • Fonction : Auteur
Javier Yugueros Marcos
  • Fonction : Auteur
Laurence Vachot
  • Fonction : Auteur
Achille Massougbodji
  • Fonction : Auteur
Nadine Fievet
  • Fonction : Auteur
Michel Cot
  • Fonction : Auteur
Valérie Briand
  • Fonction : Auteur

Résumé

BACKGROUND: Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection. METHODS: In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. Infant's febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant's hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. RESULTS: The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant's febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant's Hb concentration during the first 3 months. CONCLUSION: We evidenced the deleterious effect of maternal parasitic infections on infant's health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

Dates et versions

hal-02294238 , version 1 (23-09-2019)

Identifiants

Citer

Gino Agbota, Katja Polman, Frank T. Wieringa, Maiza Campos-Ponce, Manfred Accrombessi, et al.. Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin. PLoS ONE, 2019, 14 (9), pp.e0222864. ⟨10.1371/journal.pone.0222864⟩. ⟨hal-02294238⟩
32 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More