Optimization of a low pressure plasma process for fabrication of a Drug Delivery System (DDS) for cancer treatment

Alibi Baitukha (1) , Iman Al-Dybiat (2) , Azadeh Valinataj Omran (2) , Jérôme Pulpytel (1) , Marc Pocard , Massoud Mirshahi (2) , Farzaneh Arefi-Khonsari (1)

1 LISE - Laboratoire Interfaces et Systèmes Electrochimiques
2 CART U965 - Carcinose Angiogenèse et Recherche Translationnelle ; Angiogenese et recherche translationnelle

A low pressure ICP plasma setup was utilized to deposit thin organic barrier coatings on various substrates to fabricate DDS with encapsulated Carboplatin as a drug and Methylene Blue as a drug model. Choice of the substrates and optimal plasma parameters were discussed for the fabrication of DDS with required characteristics. Prepared thin films were analysed by FTIR, SEM, and the barrier properties were studied by measuring drug concentration released into the medium by UV-VIS and ICP-MS techniques.

Mots clés: Plasma; Drug Delivery System; DDS

Domaines: Chimie; Plasmas

Alibi Baitukha, Iman Al-Dybiat, Azadeh Valinataj Omran, Jérôme Pulpytel, Marc Pocard, et al.. Optimization of a low pressure plasma process for fabrication of a Drug Delivery System (DDS) for cancer treatment. Materials Science and Engineering: C, 2019, 105, pp.110089. ⟨10.1016/j.msec.2019.110089⟩. ⟨hal-02289769⟩