Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

Guillaume Dumas (1, 2) , Alexandre Demoule (3, 3) , Djamel Mokart (4) , Virginie Lemiale (2) , Saad Nseir (5, 6) , Laurent Argaud (7) , Frédéric Pène (8) , Loay Kontar (9) , Fabrice Bruneel (10) , Kada Klouche (11, 12) , François Barbier (13) , Jean Reignier (14) , Annabelle Stoclin (15) , Guillaume Louis (16) , Jean-Michel Constantin (3) , Florent Wallet (17) , Achille Kouatchet (18) , Vincent Peigne (19) , Pierre Perez (20) , Christophe Girault (21) , Samir Jaber (12, 11) , Yves Cohen (22) , Martine Nyunga (23) , Nicolas Terzi (24) , Lila Bouadma (25) , Christine Lebert (26) , Alexandre Lautrette (27) , Naïke Bigé (28) , Jean-Herlé Raphalen (29) , Laurent Papazian (30) , Dominique Benoit (31) , Michael Darmon (32) , Sylvie Chevret (2) , Elie Azoulay (33, 32)

1 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
2 AP-HP - Hopital Saint-Louis [AP-HP]
3 CHU Pitié-Salpêtrière [AP-HP]
4 Intensive Care Unit, IPC,
5 Urgence respiratoire et réanimation médicale
6 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
7 Hôpital Edouard Herriot [CHU - HCL]
8 Hôpital Cochin [AP-HP]
9 CHU Amiens-Picardie
10 CHV - Centre Hospitalier de Versailles André Mignot
11 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
12 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
13 La Source Hospital-CHR
14 CHU Nantes - Centre Hospitalier Universitaire de Nantes
15 IGR - Institut Gustave Roussy
16 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
17 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
18 CHU Angers - Centre Hospitalier Universitaire d'Angers
19 Centre Hospitalier Métropole-Savoie,
20 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
21 CHU Rouen
22 Hôpital Avicenne [AP-HP]
23 Centre Hospitalier de Roubaix
24 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
25 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
26 Centre Hospitalier Départemental Les Oudairies,
27 Unité de soins intensifs [Clermont Ferrand]
28 CHU Saint-Antoine [AP-HP]
29 Hôpital Necker - Enfants Malades [AP-HP]
30 AP‐MM Marseille - Hôpital Nord AP‐MM Marseille, France
31 Ghent University Hospital [Ghent, Belgium]
32 Hôpital Saint-Louis
33 Service de réanimation médicale

Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients, and the need for invasive mechanical ventilation has become a major clinical endpoint in randomized controlled trials (RCTs). However, data are lacking on whether intubation is an objective criteria that is used unbiasedly across centers. This study explores how this outcome varies across ICUs.

Mots clés: Center effect; Hypoxemia; Intubation; Leukemia; Neutropenia

Domaines: Sciences du Vivant [q-bio]

Guillaume Dumas, Alexandre Demoule, Djamel Mokart, Virginie Lemiale, Saad Nseir, et al.. Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure. Critical Care, 2019, 23 (1), pp.306. ⟨10.1186/s13054-019-2590-7⟩. ⟨hal-02281121⟩