Investigation and modeling of Residence Time Distribution and thermal dissipation in a Dynamic Filtration module

Xiaomin Xie (1) , Christophe Andre (2, 3, 4) , Nicolas Dietrich (1, 5) , Philippe Schmitz (1, 5) , Luc Fillaudeau (1, 5)

1 LISBP - Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés
2 UMET - Unité Matériaux et Transformations - UMR 8207
3 PIHM - Processus aux Interfaces et Hygiène des Matériaux
4 HEI - Hautes Etudes d’Ingénieur [Lille]
5 FERMAT - Fédération de Recherche Fluides, Energie, Réacteurs, Matériaux et Transferts

Bioprocess often associates bioreactor and membrane separation. Bioprocess performances are intrinsically related to the capacity to control and to maintain microbial cells to their optimal activity (integrity, viability and productivity) while industrial operating conditions generate stressful environment or at least no ideal conditions. In present case, high shear rates and Joule effects are generated within a specific dynamic filtration module. Then, Residence Time Distribution (RTD) in a module, named Rotating and Vibrating Filtration (RVF), in which a three-blade impeller rotates between two membranes, was studied in laminar (Remixing<1×103) and turbulent (Remixing>3×104) regimes. In addition, thermal effects of mixing rate under several flow rates and regimes were reported. The magnitude and duration of stressful conditions stand as critical parameters which were quantified and modeled to engineer and to design intensive bioprocess.

Mots clés: dynamic filtration; residence time distribution; thermal effect; modeling; systemic approach

Mots clés: bioprocédé; bioréacteur

Domaines: Biotechnologies

Xiaomin Xie, Christophe Andre, Nicolas Dietrich, Philippe Schmitz, Luc Fillaudeau. Investigation and modeling of Residence Time Distribution and thermal dissipation in a Dynamic Filtration module. 16. Congrès de la société française de génie des procédés (SFGP 2017), Jul 2017, Nancy, France. ⟨hal-02273366⟩