Buchwald–Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst

Yin Zhang (1) , Guy Lavigne (1) , Vincent César (1)

1 LCC - Laboratoire de chimie de coordination

The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr(NMe2)2 incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.

Domaines: Chimie de coordination

Yin Zhang, Guy Lavigne, Vincent César. Buchwald–Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst. Journal of Organic Chemistry, 2015, 80 (15), pp.7666-7673. ⟨10.1021/acs.joc.5b01272⟩. ⟨hal-02271027⟩