Solvent-free microwave-assisted Meyers’ lactamization

Mouhamad Jida (1) , Rebecca Deprez-Poulain (1) , Sandra Malaquin (1) , Pascal Roussel (2) , Francine Agbossou-Niedercorn (2) , Benoit Déprez (1) , Guillaume Laconde (1)

1 Biostructures et Decouverte de Medicament
2 UCCS - Unité de Catalyse et Chimie du Solide - UMR 8181

Microwave solvent-free conditions developed for Meyers’ lactamization, a typical bielectrophile-binucleophile reaction that produces quaternary centers in a stereoselective manner, give access to Meyers’ chiral lactams in good yield and high diastereoselectivity in short times.

Domaines: Chimie inorganique

Mouhamad Jida, Rebecca Deprez-Poulain, Sandra Malaquin, Pascal Roussel, Francine Agbossou-Niedercorn, et al.. Solvent-free microwave-assisted Meyers’ lactamization. Green Chemistry, 2010, 12, pp.961-964. ⟨10.1039/b924111f⟩. ⟨hal-02269383⟩