N. Albelda and J. D. , Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates, Neuroscience and biobehavioral reviews, vol.36, pp.47-63, 2012.

M. Amalric, S. Lopez, C. Goudet, G. Fisone, G. Battaglia et al., Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease, Neuropharmacology, vol.66, pp.53-64, 2013.

E. Andari, J. R. Duhamel, T. Zalla, E. Herbrecht, M. Leboyer et al., Promoting social behavior with oxytocin in high-functioning autism spectrum disorders, Proc Natl Acad Sci U S A, vol.107, pp.4389-94, 2010.

A. Argyropoulos, K. L. Gilby, and E. L. Hill-yardin, Studying autism in rodent models: reconciling endophenotypes with comorbidities, Front Hum Neurosci, vol.7, p.417, 2013.

R. L. Aupperle and M. P. Paulus, Neural systems underlying approach and avoidance in anxiety disorders, Dialogues Clin Neurosci, vol.12, pp.517-548, 2010.

M. Bortolato and J. C. Shih, Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence, International review of neurobiology, vol.100, pp.13-42, 2011.

S. R. Bradley, D. G. Standaert, K. J. Rhodes, H. D. Rees, C. M. Testa et al., Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia, The Journal of comparative neurology, vol.407, pp.33-46, 1999.

J. P. Burkett, L. L. Spiegel, K. Inoue, A. Z. Murphy, and L. J. Young, Activation of mu-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles, Neuropsychopharmacology, vol.36, pp.2200-2210, 2011.

J. D. Buxbaum, C. Betancur, O. Bozdagi, N. P. Dorr, G. A. Elder et al., Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features, Mol Autism, vol.3, p.1, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00672942

G. C. Carlson, Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders, Pharmacology, biochemistry, and behavior, vol.100, pp.850-854, 2012.

C. Chevallier, G. Kohls, V. Troiani, E. S. Brodkin, and R. T. Schultz, The social motivation theory of autism, Trends Cogn Sci, vol.16, pp.231-240, 2012.

C. Cinque, S. Pondiki, D. Oddi, D. Certo, M. G. Marinelli et al., Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice, Translational psychiatry, vol.2, p.155, 2012.

C. Corti, L. Aldegheri, P. Somogyi, and F. Ferraguti, Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS, Neuroscience, vol.110, pp.403-423, 2002.

J. N. Crawley, Mouse behavioral assays relevant to the symptoms of autism, Brain pathology, vol.17, pp.448-59, 2007.

E. B. Defensor, M. J. Corley, R. J. Blanchard, and D. C. Blanchard, Facial expressions of mice in aggressive and fearful contexts, Physiol Behav, vol.107, pp.680-685, 2012.

R. Delorme, E. Ey, R. Toro, M. Leboyer, C. Gillberg et al., Progress toward treatments for synaptic defects in autism, Nature medicine, vol.19, pp.685-94, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01470299

D. Martino, A. Kelly, C. Grzadzinski, R. Zuo, X. N. Mennes et al., Aberrant striatal functional connectivity in children with autism, Biological psychiatry, vol.69, pp.847-56, 2011.

G. Dichter and R. Adolphs, Reward processing in autism: a thematic series, J Neurodev Disord, vol.4, p.20, 2012.

G. S. Dichter, J. A. Richey, A. M. Rittenberg, A. Sabatino, and J. W. Bodfish, Reward circuitry function in autism during face anticipation and outcomes, J Autism Dev Disord, vol.42, pp.147-60, 2012.

G. Dolen, A. Darvishzadeh, K. W. Huang, and R. C. Malenka, Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin, Nature, vol.501, pp.179-84, 2013.

R. M. Duvoisin, L. Villasana, M. J. Davis, D. G. Winder, and J. Raber, Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges, Behav Brain Res, vol.221, pp.50-54, 2011.

C. Ecker, W. Spooren, and D. G. Murphy, Translational approaches to the biology of Autism: false dawn or a new era? Molecular psychiatry, 2012.

C. Ecker, J. Suckling, S. C. Deoni, M. V. Lombardo, E. T. Bullmore et al., Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging study, Arch Gen Psychiatry, vol.69, pp.195-209, 2012.

D. Filliol, S. Ghozland, J. Chluba, M. Martin, H. W. Matthes et al., Mice deficient for delta-and mu-opioid receptors exhibit opposing alterations of emotional responses, Nature genetics, vol.25, pp.195-200, 2000.

C. Gaveriaux-ruff and B. L. Kieffer, Opioid receptor genes inactivated in mice: the highlights, Neuropeptides, vol.36, pp.62-71, 2002.

G. Grecksch, A. Becker, H. Schroeder, J. Kraus, H. Loh et al., Accelerated kindling development in mu-opioid receptor deficient mice, Naunyn-Schmiedeberg's archives of pharmacology, vol.369, pp.287-93, 2004.

D. Green, T. Charman, A. Pickles, S. Chandler, T. Loucas et al., Impairment in movement skills of children with autistic spectrum disorders, Dev Med Child Neurol, vol.51, pp.311-317, 2009.

J. Horder, T. Lavender, M. A. Mendez, R. O'gorman, E. Daly et al., Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [(1)H]MRS study, Translational psychiatry, vol.3, p.279, 2013.

D. T. Hsu, B. J. Sanford, K. K. Meyers, T. M. Love, K. E. Hazlett et al., Response of the mu-opioid system to social rejection and acceptance. Molecular psychiatry, 2013.

S. Ide, I. Sora, K. Ikeda, M. Minami, G. R. Uhl et al., Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice, Neuropharmacology, vol.58, pp.241-248, 2010.

T. R. Insel, The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior, Neuron, vol.65, pp.768-79, 2010.

L. Jamot, H. W. Matthes, F. Simonin, B. L. Kieffer, and J. C. Roder, Differential involvement of the mu and kappa opioid receptors in spatial learning, Genes Brain Behav, vol.2, pp.80-92, 2003.

C. G. Jang, S. Y. Lee, H. H. Loh, and I. K. Ho, Lack of mu-opioid receptor leads to an increase in the NMDA receptor subunit mRNA expression and NMDA-induced convulsion, Brain research Molecular brain research, vol.94, pp.105-116, 2001.

C. P. Johnson and S. M. Myers, Identification and evaluation of children with autism spectrum disorders, Pediatrics, vol.120, pp.1183-215, 2007.

M. A. Just, T. A. Keller, V. L. Malave, R. K. Kana, and S. Varma, Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity, Neuroscience and biobehavioral reviews, vol.36, pp.1292-313, 2012.

R. J. Kelleher, U. Geigenmuller, H. Hovhannisyan, E. Trautman, R. Pinard et al., High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism, PLoS One, vol.7, p.35003, 2012.

G. Kohls, M. Schulte-ruther, B. Nehrkorn, K. Muller, G. R. Fink et al., Reward system dysfunction in autism spectrum disorders, Soc Cogn Affect Neurosci, 2012.

K. S. Lam, M. G. Aman, and L. E. Arnold, Neurochemical correlates of autistic disorder: a review of the literature, Res Dev Disabil, vol.27, pp.254-89, 2006.

L. Merrer, J. Becker, J. A. Befort, K. Kieffer, and B. L. , Reward processing by the opioid system in the brain, Physiol Rev, vol.89, pp.1379-412, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00438654

L. Merrer, J. Befort, K. Gardon, O. Filliol, D. Darcq et al., Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network, Addiction biology, vol.17, pp.1-12, 2012.

L. Merrer, J. Rezai, X. Scherrer, G. Becker, J. A. Kieffer et al., Impaired HippocampusDependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor, Neuropsychopharmacology, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02266437

A. R. Maher and G. Theodore, Summary of the comparative effectiveness review on off-label use of atypical antipsychotics, Journal of managed care pharmacy, vol.18, pp.1-20, 2012.

H. W. Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe et al., Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene, Nature, vol.383, pp.819-842, 1996.

M. O. Mazurek, R. A. Vasa, L. G. Kalb, S. M. Kanne, D. Rosenberg et al., Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders, Journal of abnormal child psychology, vol.41, pp.165-76, 2013.

A. Moles, B. L. Kieffer, D. Amato, and F. R. , Deficit in attachment behavior in mice lacking the mu-opioid receptor gene, Science, vol.304, pp.1983-1989, 2004.

E. Neuhaus, T. P. Beauchaine, and R. Bernier, Neurobiological correlates of social functioning in autism, Clinical psychology review, vol.30, pp.733-781, 2010.

D. Oddi, W. E. Crusio, D. 'amato, F. R. Pietropaolo, and S. , Monogenic mouse models of social dysfunction: implications for autism, Behav Brain Res, vol.251, pp.75-84, 2013.

J. Peca, C. Feliciano, J. T. Ting, W. Wang, M. F. Wells et al., Shank3 mutant mice display autistic-like behaviours and striatal dysfunction, Nature, vol.472, pp.437-479, 2011.

O. Penagarikano, B. S. Abrahams, E. I. Herman, K. D. Winden, A. Gdalyahu et al., Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits, Cell, vol.147, pp.235-281, 2011.

J. M. Rawleigh and E. D. Kemble, Test-specific effects of FG-7142 on isolation-induced aggression in mice, Pharmacology, biochemistry, and behavior, vol.42, pp.317-338, 1992.

H. R. Robertson and G. Feng, Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders, J Child Psychol Psychiatry, vol.52, pp.442-75, 2011.

S. J. Robinson, Childhood epilepsy and autism spectrum disorders: psychiatric problems, phenotypic expression, and anticonvulsants, Neuropsychology review, vol.22, pp.271-280, 2012.

D. C. Rojas, D. Singel, S. Steinmetz, S. Hepburn, and M. S. Brown, Decreased left perisylvian GABA concentration in children with autism and unaffected siblings, Neuroimage, 2013.

S. Roy, H. C. Liu, and H. H. Loh, mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit, Brain research Molecular brain research, vol.56, pp.281-284, 1998.

D. Sato, A. C. Lionel, C. S. Leblond, A. Prasad, D. Pinto et al., SHANK1 Deletions in Males with Autism Spectrum Disorder, vol.90, pp.879-87, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01580198

A. Slawinska, J. M. Wieronska, K. Stachowicz, A. Palucha-poniewiera, M. A. Uberti et al., Anxiolytic-but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu(4) receptor, Neuropharmacology, vol.66, pp.225-260, 2013.

M. W. State and P. Levitt, The conundrums of understanding genetic risks for autism spectrum disorders, Nat Neurosci, vol.14, pp.1499-506, 2011.

C. M. Testa, D. G. Standaert, A. B. Young, J. B. Penney, and J. , Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat, J Neurosci, vol.14, pp.3005-3023, 1994.

V. Trezza, P. J. Baarendse, and L. J. Vanderschuren, The pleasures of play: pharmacological insights into social reward mechanisms, Trends in pharmacological sciences, vol.31, pp.463-472, 2010.

V. Trezza, R. Damsteegt, E. J. Achterberg, and L. J. Vanderschuren, Nucleus accumbens muopioid receptors mediate social reward, J Neurosci, vol.31, pp.6362-70, 2011.

A. Troisi, G. Frazzetto, C. V. , D. Lorenzo, G. Coviello et al., Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients, Social neuroscience, vol.6, pp.88-97, 2011.

L. W. Van-kerkhof, V. Trezza, T. Mulder, P. Gao, P. Voorn et al., Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates, Neuroscience and biobehavioral reviews, vol.36, pp.47-63, 2012.

M. Amalric, S. Lopez, C. Goudet, G. Fisone, G. Battaglia et al., Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease, Neuropharmacology, vol.66, pp.53-64, 2013.

E. Andari, J. R. Duhamel, T. Zalla, E. Herbrecht, M. Leboyer et al., Promoting social behavior with oxytocin in high-functioning autism spectrum disorders, Proc Natl Acad Sci U S A, vol.107, pp.4389-94, 2010.

A. Argyropoulos, K. L. Gilby, and E. L. Hill-yardin, Studying autism in rodent models: reconciling endophenotypes with comorbidities, Front Hum Neurosci, vol.7, p.417, 2013.

R. L. Aupperle and M. P. Paulus, Neural systems underlying approach and avoidance in anxiety disorders, Dialogues Clin Neurosci, vol.12, pp.517-548, 2010.

M. Bortolato and J. C. Shih, Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence, International review of neurobiology, vol.100, pp.13-42, 2011.

S. R. Bradley, D. G. Standaert, K. J. Rhodes, H. D. Rees, C. M. Testa et al., Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia, The Journal of comparative neurology, vol.407, pp.33-46, 1999.

J. P. Burkett, L. L. Spiegel, K. Inoue, A. Z. Murphy, and L. J. Young, Activation of mu-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles, Neuropsychopharmacology, vol.36, pp.2200-2210, 2011.

J. D. Buxbaum, C. Betancur, O. Bozdagi, N. P. Dorr, G. A. Elder et al., Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features, Mol Autism, vol.3, p.1, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00672942

G. C. Carlson, Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders, Pharmacology, biochemistry, and behavior, vol.100, pp.850-854, 2012.

C. Chevallier, G. Kohls, V. Troiani, E. S. Brodkin, and R. T. Schultz, The social motivation theory of autism, Trends Cogn Sci, vol.16, pp.231-240, 2012.

C. Cinque, S. Pondiki, D. Oddi, D. Certo, M. G. Marinelli et al., Modeling socially anhedonic syndromes: genetic and pharmacological manipulation of opioid neurotransmission in mice, Translational psychiatry, vol.2, p.155, 2012.

C. Corti, L. Aldegheri, P. Somogyi, and F. Ferraguti, Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS, Neuroscience, vol.110, pp.403-423, 2002.

J. N. Crawley, Mouse behavioral assays relevant to the symptoms of autism, Brain pathology, vol.17, pp.448-59, 2007.

E. B. Defensor, M. J. Corley, R. J. Blanchard, and D. C. Blanchard, Facial expressions of mice in aggressive and fearful contexts, Physiol Behav, vol.107, pp.680-685, 2012.

R. Delorme, E. Ey, R. Toro, M. Leboyer, C. Gillberg et al., Progress toward treatments for synaptic defects in autism, Nature medicine, vol.19, pp.685-94, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01470299

D. Martino, A. Kelly, C. Grzadzinski, R. Zuo, X. N. Mennes et al., Aberrant striatal functional connectivity in children with autism, Biological psychiatry, vol.69, pp.847-56, 2011.

G. Dichter and R. Adolphs, Reward processing in autism: a thematic series, J Neurodev Disord, vol.4, p.20, 2012.

G. S. Dichter, J. A. Richey, A. M. Rittenberg, A. Sabatino, and J. W. Bodfish, Reward circuitry function in autism during face anticipation and outcomes, J Autism Dev Disord, vol.42, pp.147-60, 2012.

G. Dolen, A. Darvishzadeh, K. W. Huang, and R. C. Malenka, Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin, Nature, vol.501, pp.179-84, 2013.

R. M. Duvoisin, L. Villasana, M. J. Davis, D. G. Winder, and J. Raber, Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges, Behav Brain Res, vol.221, pp.50-54, 2011.

C. Ecker, W. Spooren, and D. G. Murphy, Translational approaches to the biology of Autism: false dawn or a new era? Molecular psychiatry, 2012.

C. Ecker, J. Suckling, S. C. Deoni, M. V. Lombardo, E. T. Bullmore et al., Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging study, Arch Gen Psychiatry, vol.69, pp.195-209, 2012.

D. Filliol, S. Ghozland, J. Chluba, M. Martin, H. W. Matthes et al., Mice deficient for delta-and mu-opioid receptors exhibit opposing alterations of emotional responses, Nature genetics, vol.25, pp.195-200, 2000.

C. Gaveriaux-ruff and B. L. Kieffer, Opioid receptor genes inactivated in mice: the highlights, Neuropeptides, vol.36, pp.62-71, 2002.

G. Grecksch, A. Becker, H. Schroeder, J. Kraus, H. Loh et al., Accelerated kindling development in mu-opioid receptor deficient mice, Naunyn-Schmiedeberg's archives of pharmacology, vol.369, pp.287-93, 2004.

D. Green, T. Charman, A. Pickles, S. Chandler, T. Loucas et al., Impairment in movement skills of children with autistic spectrum disorders, Dev Med Child Neurol, vol.51, pp.311-317, 2009.

J. Horder, T. Lavender, M. A. Mendez, R. O'gorman, E. Daly et al., Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [(1)H]MRS study, Translational psychiatry, vol.3, p.279, 2013.

D. T. Hsu, B. J. Sanford, K. K. Meyers, T. M. Love, K. E. Hazlett et al., Response of the mu-opioid system to social rejection and acceptance. Molecular psychiatry, 2013.

S. Ide, I. Sora, K. Ikeda, M. Minami, G. R. Uhl et al., Reduced emotional and corticosterone responses to stress in mu-opioid receptor knockout mice, Neuropharmacology, vol.58, pp.241-248, 2010.

T. R. Insel, The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior, Neuron, vol.65, pp.768-79, 2010.

L. Jamot, H. W. Matthes, F. Simonin, B. L. Kieffer, and J. C. Roder, Differential involvement of the mu and kappa opioid receptors in spatial learning, Genes Brain Behav, vol.2, pp.80-92, 2003.

C. G. Jang, S. Y. Lee, H. H. Loh, and I. K. Ho, Lack of mu-opioid receptor leads to an increase in the NMDA receptor subunit mRNA expression and NMDA-induced convulsion, Brain research Molecular brain research, vol.94, pp.105-116, 2001.

C. P. Johnson and S. M. Myers, Identification and evaluation of children with autism spectrum disorders, Pediatrics, vol.120, pp.1183-215, 2007.

M. A. Just, T. A. Keller, V. L. Malave, R. K. Kana, and S. Varma, Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity, Neuroscience and biobehavioral reviews, vol.36, pp.1292-313, 2012.

R. J. Kelleher, U. Geigenmuller, H. Hovhannisyan, E. Trautman, R. Pinard et al., High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism, PLoS One, vol.7, p.35003, 2012.

G. Kohls, M. Schulte-ruther, B. Nehrkorn, K. Muller, G. R. Fink et al., Reward system dysfunction in autism spectrum disorders, Soc Cogn Affect Neurosci, 2012.

K. S. Lam, M. G. Aman, and L. E. Arnold, Neurochemical correlates of autistic disorder: a review of the literature, Res Dev Disabil, vol.27, pp.254-89, 2006.

L. Merrer, J. Becker, J. A. Befort, K. Kieffer, and B. L. , Reward processing by the opioid system in the brain, Physiol Rev, vol.89, pp.1379-412, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00438654

L. Merrer, J. Befort, K. Gardon, O. Filliol, D. Darcq et al., Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network, Addiction biology, vol.17, pp.1-12, 2012.

L. Merrer, J. Rezai, X. Scherrer, G. Becker, J. A. Kieffer et al., Impaired HippocampusDependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor, Neuropsychopharmacology, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02266437

A. R. Maher and G. Theodore, Summary of the comparative effectiveness review on off-label use of atypical antipsychotics, Journal of managed care pharmacy, vol.18, pp.1-20, 2012.

H. W. Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe et al., Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene, Nature, vol.383, pp.819-842, 1996.

M. O. Mazurek, R. A. Vasa, L. G. Kalb, S. M. Kanne, D. Rosenberg et al., Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders, Journal of abnormal child psychology, vol.41, pp.165-76, 2013.

A. Moles, B. L. Kieffer, D. Amato, and F. R. , Deficit in attachment behavior in mice lacking the mu-opioid receptor gene, Science, vol.304, pp.1983-1989, 2004.

E. Neuhaus, T. P. Beauchaine, and R. Bernier, Neurobiological correlates of social functioning in autism, Clinical psychology review, vol.30, pp.733-781, 2010.

D. Oddi, W. E. Crusio, D. 'amato, F. R. Pietropaolo, and S. , Monogenic mouse models of social dysfunction: implications for autism, Behav Brain Res, vol.251, pp.75-84, 2013.

J. Peca, C. Feliciano, J. T. Ting, W. Wang, M. F. Wells et al., Shank3 mutant mice display autistic-like behaviours and striatal dysfunction, Nature, vol.472, pp.437-479, 2011.

O. Penagarikano, B. S. Abrahams, E. I. Herman, K. D. Winden, A. Gdalyahu et al., Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits, Cell, vol.147, pp.235-281, 2011.

L. B. Pouw, C. Rieffe, P. Oosterveld, B. Huskens, and L. Stockmann, Reactive/proactive aggression and affective/cognitive empathy in children with ASD, Res Dev Disabil, vol.34, pp.1256-66, 2013.

J. M. Rawleigh and E. D. Kemble, Test-specific effects of FG-7142 on isolation-induced aggression in mice, Pharmacology, biochemistry, and behavior, vol.42, pp.317-338, 1992.

H. R. Robertson and G. Feng, Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders, J Child Psychol Psychiatry, vol.52, pp.442-75, 2011.

S. J. Robinson, Childhood epilepsy and autism spectrum disorders: psychiatric problems, phenotypic expression, and anticonvulsants, Neuropsychology review, vol.22, pp.271-280, 2012.

D. C. Rojas, D. Singel, S. Steinmetz, S. Hepburn, and M. S. Brown, Decreased left perisylvian GABA concentration in children with autism and unaffected siblings, Neuroimage, 2013.

S. Roy, H. C. Liu, and H. H. Loh, mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit, Brain research Molecular brain research, vol.56, pp.281-284, 1998.

D. Sato, A. C. Lionel, C. S. Leblond, A. Prasad, D. Pinto et al., SHANK1 Deletions in Males with Autism Spectrum Disorder, vol.90, pp.879-87, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01580198

A. Slawinska, J. M. Wieronska, K. Stachowicz, A. Palucha-poniewiera, M. A. Uberti et al., Anxiolytic-but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu(4) receptor, Neuropharmacology, vol.66, pp.225-260, 2013.

M. W. State and P. Levitt, The conundrums of understanding genetic risks for autism spectrum disorders, Nat Neurosci, vol.14, pp.1499-506, 2011.

C. M. Testa, D. G. Standaert, A. B. Young, J. B. Penney, and J. , Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat, J Neurosci, vol.14, pp.3005-3023, 1994.

V. Trezza, P. J. Baarendse, and L. J. Vanderschuren, The pleasures of play: pharmacological insights into social reward mechanisms, Trends in pharmacological sciences, vol.31, pp.463-472, 2010.

V. Trezza, R. Damsteegt, E. J. Achterberg, and L. J. Vanderschuren, Nucleus accumbens muopioid receptors mediate social reward, J Neurosci, vol.31, pp.6362-70, 2011.

A. Troisi, G. Frazzetto, C. V. , D. Lorenzo, G. Coviello et al., Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients, Social neuroscience, vol.6, pp.88-97, 2011.

L. W. Van-kerkhof, V. Trezza, T. Mulder, P. Gao, P. Voorn et al., Cellular activation in limbic brain systems during social play behaviour in rats, Brain Struct Funct, 2013.

J. Veenstra-vanderweele and R. D. Blakely, Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments, Neuropsychopharmacology, vol.37, pp.196-212, 2012.

B. M. Way, S. E. Taylor, and N. I. Eisenberger, Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection, Proc Natl Acad Sci U S A, vol.106, pp.15079-84, 2009.

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