, Association Neurofibromatose et Recklinghausen (ANR) and Institut National du Cancer
NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions, Genes Dev, vol.17, pp.1090-1100, 2003. ,
The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation, Genes & Dev, vol.11, pp.1253-1265, 1997. ,
Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2, Genes & Dev, vol.14, pp.1617-1630, 2000. ,
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1, Mol Cell, vol.12, pp.841-849, 2003. ,
An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin), J. Biol. Chem, vol.269, pp.23387-23390, 1994. ,
Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac, Cancer Res, vol.67, pp.520-527, 2007. ,
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth, Mol. Cell. Biol, vol.29, pp.4250-4261, 2009. ,
The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling, Curr. Biol, vol.16, pp.702-709, 2006. ,
Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas, Oncogene, vol.28, pp.854-865, 2009. ,
, , 2010.
, Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus, Cell, vol.140, pp.477-490
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals, Dev. Cell, vol.19, pp.27-38, 2010. ,
Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded, Dev Cell, vol.40, pp.478-490, 2017. ,
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus, Cancer cell, vol.26, issue.1, pp.48-60, 2014. ,
Proteomic screening identifies a YAPdriven signaling network linked to tumor cell proliferation in human schwannomas, Neuro Oncol, vol.16, issue.9, pp.1196-209, 2014. ,
YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis, Cancer Research, vol.76, pp.3507-3519, 2016. ,
Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin, Oncogene, vol.24, pp.1150-1158, 2005. ,
A functional association between merlin and HEI10, a cell cycle regulator, Oncogene, vol.25, pp.4389-4398, 2006. ,
, , 2012.
ERM proteins establish cortical asymmetry and centrosome position, Genes Dev, vol.26, pp.2709-2723 ,
Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells, J. Cell Biol, vol.180, pp.739-746, 2008. ,
Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis, Curr. Biol, vol.18, pp.91-101, 2008. ,
The actin-binding ERM protein Moesin binds to and stabilizes microtubules at the cell cortex, J. Cell Biol, vol.202, issue.2, pp.251-260, 2013. ,
SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation, J. Cell Biol, vol.205, issue.6, pp.791-799, 2014. ,
The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton, Human Molecular Genetics, vol.16, issue.14, pp.1742-1751, 2007. ,
Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer, Cancer Res, vol.74, pp.353-362, 2014. ,
, kinase activities in mitotic cells, Sci Signal, vol.4, issue.179
Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein, Genes & Dev, vol.13, pp.978-986, 1999. ,
The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis, Cell Cycle, vol.10, issue.16, pp.2724-2760, 2011. ,
Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin, Neoplasia, vol.13, pp.643-652, 2011. ,
Aurora A's Functions During Mitotic Exit: The Guess Who Game, Front Oncol, vol.5, p.290, 2015. ,
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis, Dev Cell, vol.18, pp.533-543, 2010. ,
The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state, Dev. Cell, vol.22, issue.4, pp.703-708, 2012. ,
, , 2004.
, Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin, J Cell Biol, vol.164, issue.5, pp.653-659
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus, EMBO reports, vol.13, issue.3, pp.204-215, 2012. ,
Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling, Mol Cell Biol, vol.29, pp.4235-4249, 2009. ,
Organizing the cell cortex: the role of ERM proteins, Nat Rev Mol Cell Biol, vol.11, pp.276-287, 2010. ,
The Hippo signaling pathway in development and cancer, Dev Cell, vol.19, pp.491-505, 2010. ,
The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling, Dev. Biol, vol.304, pp.102-115, 2007. ,
Regulation of localization and function of the transcriptional co-activator YAP by angiomotin, vol.6, p.23966, 2016. ,
Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation, J Cell Sci, vol.131, issue.10, 2018. ,
Interaction between two isoforms of the NF2 tumor suppressor protein, Merlin, and between Merlin and ezrin, suggests modulation of ERM proteins by Merlin, Neurosci Res, vol.62, issue.4, pp.491-502, 2000. ,
Linking abnormal mitosis to the acquisition of DNA damage, J Cell Biol, vol.199, issue.6, pp.871-81, 2012. ,
A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2, Human Genet, vol.97, issue.2, pp.224-231, 1996. ,
Type of mutation in the neurofibromatosis type 2 gene (NF2) frequently determines severity of disease, Am J Hum Genet, vol.59, issue.2, pp.331-373, 1996. ,
Predictors of the risk of mortality in neurofibromatosis 2, Am J Hum Genet, vol.71, issue.4, pp.715-738, 2002. ,
A missense mutation in the neurofibromatosis 2 gene occurs in patients with mild and severe phenotypes, Neurology, vol.47, issue.2, pp.544-550, 1996. ,
Interdomain binding mediates tumor growth suppression by the NF2 gene product, Oncogene, vol.15, pp.2505-2509, 1997. ,
Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells, J Cell Sci, vol.122, pp.4141-4149, 2009. ,
Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity, J Cell Mol Med, vol.16, pp.2161-2175, 2012. ,
ERM proteins and merlin: integrators at the cell cortex, Nat Rev Mol Cell Biol, vol.3, pp.586-599, 2002. ,
Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy, Nat Neurosci, vol.16, pp.426-433, 2013. ,
Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2, Nat Commun, vol.9, issue.1, p.1338, 2018. ,
The conformation change and tumor suppressor role of Merlin are both independent of Serine 518 phosphorylation, Biochem Biophys Res Commun, vol.493, issue.1, pp.46-51, 2017. ,