A Dietary Intervention of Bioactive Enriched Foods Aimed at Adults at Risk of Metabolic Syndrome: Protocol and Results from PATHWAY-27 Pilot Study

A. Bub (1) , Corinne Malpuech Brugère (2, 3) , C. Orfila (4, 5) , J Amat (2, 3) , A. Arianna (1) , A. Blot (6, 3) , M. Di Nunzio (7) , M. Holmes (4, 5) , Z. Kertesz (8) , L. Marshall (4, 5) , I. Nemeth (9) , L. Ricciardiello (10) , S. Seifert (1) , S. Sutulic (4, 5) , M. Ulaszewska (11) , A. Bordoni (7)

1 Department of Physiology and Biochemistry of Nutrition
2 UNH - Unité de Nutrition Humaine
3 Centre de Recherche en Nutrition Humaine
4 School of Food Science and Nutrition
5 University of Leeds
6 CHU Clermont-Ferrand
7 Department of Agri-Food Sciences and Technologies (DISTAL)
8 Campden BRI Hungary Ltd
9 AdWare Research Ltd
10 Department of Medical and Surgical Sciences
11 Dipartimento Qualità Alimentare e Nutrizione

Around a quarter of the global adult population have metabolic syndrome (MetS) and therefore increased risk of cardiovascular mortality and diabetes. Docosahexaenoic acid, oat beta-glucan and grape anthocyanins have been shown to be effective in reducing MetS risk factors when administered as isolated compounds, but their effect when administered as bioactive-enriched foods has not been evaluated. OBJECTIVE: The overall aim of the PATHWAY-27 project was to evaluate the effectiveness of bioactive-enriched food consumption on improving risk factors of MetS. A pilot study was conducted to assess which of five bioactive combinations provided within three different food matrices (bakery, dairy or egg) were the most effective in adult volunteers. The trial also evaluated the feasibility of production, consumer acceptability and gastrointestinal tolerance of the bioactive-enriched food. METHOD: The study included three monocentric, parallel-arm, double-blind, randomised, dietary intervention trials without a placebo. Each recruiting centre tested the five bioactive combinations within a single food matrix. RESULTS: The study was completed by 167 participants (74 male, 93 female). The results indicated that specific bioactive/matrix combinations have effects on serum triglyceride or HDL-cholesterol level without adverse effects. CONCLUSION: The study evidenced that bioactive-enriched food offers a promising food-based strategy for MetS prevention, and highlighted the importance of conducting pilot studies.

Mots clés: bakery; bioactive; anthocyanins; dairy; docosahexaenoic acid; egg; metabolic syndrome; nutritional intervention trials; functional food; oat beta-glucan; short chain fatty acid

Domaines: Alimentation et Nutrition

A. Bub, Corinne Malpuech Brugère, C. Orfila, J Amat, A. Arianna, et al.. A Dietary Intervention of Bioactive Enriched Foods Aimed at Adults at Risk of Metabolic Syndrome: Protocol and Results from PATHWAY-27 Pilot Study. Nutrients, 2019, 11 (8), ⟨10.3390/nu11081814⟩. ⟨hal-02266294⟩