Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock

Solenn Remy (1) , Morgane Gossez (2) , Alexandre Belot (3) , Jack Hayman (4) , Aurelie Portefaix (5) , Fabienne Venet (2) , Etienne Javouhey (6) , Guillaume Monneret (2)

1 Hospices Civils de Lyon, Paediatric Intensive Care Unit
2 PI3 - Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques / Pathophysiology of Injury-induced Immunosuppression
3 Rheumatism and autoimmune diseases (RAISE)
4 Hospices Civils de Lyon, Immunology Laboratory
5 EPICIME-CIC 1407 de Lyon
6 UMRESTTE UMR T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement

Clinical presentations of hemophagocytic lymphohistiocytosis (HLH) and septic shock share many similarities, including multiple organ dysfunction and overall clinical and biological symptoms. However, these life-threatening conditions require specific and opposing treatments. Currently, no single biomarker is available to differentiate septic shock from HLH at patient admission

Mots clés: BIOMARKER; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SEPTIC SHOCK; IMMUNE RESPONSE

Mots clés: EPIDEMIOLOGIE; SANTE

Domaines: Santé publique et épidémiologie

Solenn Remy, Morgane Gossez, Alexandre Belot, Jack Hayman, Aurelie Portefaix, et al.. Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock. Critical Care, 2018, 22 (213), 2 p. ⟨10.1186/s13054-018-2146-2⟩. ⟨hal-02266062⟩