Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Jean-Michel Constantin 1 Matthieu Jabaudon 2, 1 Jean-Yves Lefrant 3 Samir Jaber 4, 5 Jean-Pierre Quenot 6 Olivier Langeron 7 Martine Ferrandiere 8 Fabien Grelon 9 Philippe Seguin 10 Carole Ichai 11 Benoit Veber 12 Bertrand Souweine 13 Thomas Uberti 14 Sigismond Lasocki 15 François Legay 16 Marc Leone 17 Nathanael Eisenmann 18 Claire Dahyot-Fizelier 19 Hervé Dupont 20 Karim Asehnoune 21 Achille Sossou 22 Gérald Chanques 4, 5 Laurent Muller 23 Jean-Etienne Bazin 24 Antoine Monsel 25 Lucile Borao 26 Jean-Marc Garcier 27 Jean-Jacques Rouby 7 Bruno Pereira 28 Emmanuel Futier 29 de Jong Audrey 4, 5
Abstract : The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients' lung morphology would improve the survival of patients with ARDS when compared with standard of care.
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https://hal.archives-ouvertes.fr/hal-02265652
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Submitted on : Sunday, August 11, 2019 - 11:29:44 AM
Last modification on : Tuesday, August 13, 2019 - 1:07:51 AM

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Jean-Michel Constantin, Matthieu Jabaudon, Jean-Yves Lefrant, Samir Jaber, Jean-Pierre Quenot, et al.. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial. The Lancet Respiratory Medicine, 2019, ⟨10.1016/S2213-2600(19)30138-9⟩. ⟨hal-02265652⟩

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