GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle

Abstract : The perifornical-lateral hypothalamic area is implicated in regulating waking and paradoxical sleep. The blockade of GABAA receptors by iontophoretic applications of bicuculline (or gabazine) into the perifornical-lateral hypothalamic area induced a continuous quiet waking state associated to a robust muscle tone in head-restrained rats. During the effects, sleep was totally suppressed. In rats killed at the end of a 90 min ejection of bicuculline, Fos expression was induced in approximately 28% of the neurons immunoreactive for hypocretin and in approximately 3% of the neurons immunostained for melanin-concentrating hormone within the ejection site. These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation.
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Submitted on : Thursday, August 8, 2019 - 1:52:24 PM
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Romain Goutagny, Pierre-Hervé Luppi, Denise Salvert, Damien Gervasoni, Patrice Fort, et al.. GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle. NeuroReport, Lippincott, Williams & Wilkins, 2005, 16 (10), pp.1069-1073. ⟨10.1097/00001756-200507130-00008⟩. ⟨hal-02265100⟩

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