Paternal age ≥ 40 years: an important risk factor for infertility

Elise de La Rochebrochard (1) , Patrick Thonneau (2)

1 Inserm U569 - Epidémiologie, Démographie et Sciences Sociales : santé reproductive, sexualité et infection à VIH
2 GRFH - Groupe de recherche en fertilité humaine

OBJECTIVE: The purpose of this study was to examine the risk of infertility that is associated with paternal age, because this factor rarely has been investigated, whereas maternal age of >or=35 years is a well-known risk factor. STUDY DESIGN: This large, retrospective, population-based sample included 6188 European women (from Denmark, Italy, Spain, Germany) aged 25 to 44 years who were selected randomly from census registers in 1991 through 1993. RESULTS: Among couples composed of a woman aged 35 to 39 years, risks were significantly higher when paternal age was >or=40 years than when paternal age was <40 years, with an adjusted odds ratio of 2.21 (95% CI, 1.13, 4.33) for delay in pregnancy onset (failure to conceive within 12 months) and of 3.02 (95% CI, 1.56, 5.85) for difficulties in having a baby (failure to conceive within 12 months or pregnancy not resulting in a live birth). CONCLUSION: Like maternal age of >or=35 years, paternal age of >or=40 years should be considered to be a key risk factor for infertility.

Mots clés: infertility; maternal age; paternal age

Domaines: Santé publique et épidémiologie; Démographie

Elise de La Rochebrochard, Patrick Thonneau. Paternal age ≥ 40 years: an important risk factor for infertility. American Journal of Obstetrics and Gynecology, 2003, 189 (4), pp.901 - 905. ⟨10.1067/s0002-9378(03)00753-1⟩. ⟨hal-02264913⟩