E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation

L. Le Cam (1) , L. K. Linares , C. Paul (2) , E. Julien (2) , M. Lacroix (3) , E. Hatchi , R. Triboulet (4) , G. Bossis (5) , A. Shmueli , M. S. Rodriguez , O. Coux (6) , C. Sardet (5)

1 NXP Semiconductors
2 CGPhiMC - Centre de génétique et de physiologie moléculaire et cellulaire
3 IMRCP - Interactions moléculaires et réactivité chimique et photochimique
4 IGH - Institut de génétique humaine
5 IGMM - Institut de Génétique Moléculaire de Montpellier
6 CRBM - Centre de recherches de biochimie macromoléculaire

Mots clés: Post-Translational Protein Structure; Tertiary Protein Transport/radiation effects Proto-Oncogene Proteins c-mdm2/metabolism Repressor Proteins/chemistry/*metabolism Sequence Homology; Genetic/radiation effects Tumor Cells; Cultured Tumor Suppressor Protein p53/*metabolism Ubiquitin-Protein Ligases/*metabolism Ultraviolet Rays p300-CBP Transcription Factors; Cell Nucleus/radiation effects Amino Acid Sequence Apoptosis/radiation effects Cell Cycle Proteins/metabolism Chromatin/metabolism Histone Acetyltransferases/metabolism Humans Lysine/metabolism Molecular Sequence Data *Protein Processing; Amino Acid Thermodynamics Transcription Factors/metabolism Transcription; Acetylation/radiation effects Active Transport

Domaines: Biochimie, Biologie Moléculaire

L. Le Cam, L. K. Linares, C. Paul, E. Julien, M. Lacroix, et al.. E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell, 2006, 127 (4), pp.775--88. ⟨10.1016/j.cell.2006.09.031⟩. ⟨hal-02262465⟩