Peptide-vector strategy bypasses P-glycoprotein efflux, and enhances brain transport and solubility of paclitaxel

E. Blanc , C. Bonnafous , P. Merida (1) , S. Cisternino , P. Clair , J. M. Scherrmann , J. Temsamani

1 IGMM - Institut de Génétique Moléculaire de Montpellier

Mots clés: Animals Antineoplastic Agents; Phytogenic/administration & dosage/chemistry/*pharmacokinetics Biological Transport Blood-Brain Barrier/*metabolism Cell Cycle/drug effects Cell Line; Tumor Drug Carriers Humans Mice Oligopeptides/*chemistry P-Glycoprotein/*metabolism Paclitaxel/administration & dosage/chemistry/*pharmacokinetics Rats Solubility Succinic Acid/chemistry

Domaines: Biochimie, Biologie Moléculaire

E. Blanc, C. Bonnafous, P. Merida, S. Cisternino, P. Clair, et al.. Peptide-vector strategy bypasses P-glycoprotein efflux, and enhances brain transport and solubility of paclitaxel. Anti-Cancer Drugs, 2004, 15 (10), pp.947--54. ⟨hal-02262373⟩