The spliceosome: a novel multi-faceted target for therapy

Abstract : The spliceosome is a dynamic and flexible ribonucleoprotein enzyme that removes intronic sequences in a regulated manner. Spliceosome action enables one stretch of genomic DNA sequence to yield several mRNAs that encode different proteins. It depends on a flexible mechanism for selecting splice sites, which calls for regulatory sequences (splicing enhancers or silencers) recognized by cognate trans-acting protein factors and constitutive ribonucleoprotein devices to build up the catalytic core. The identification of both types of elements now offers a comprehensive insight into how the spliceosome is adapted to carry out the removal of different introns and suggests novel therapeutic targets to, ultimately, restore a physiological pattern of alternatively spliced variants in a large repertoire of pathologies.
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Submitted on : Friday, August 2, 2019 - 10:58:07 AM
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J. Tazi, S. Durand, P. Jeanteur. The spliceosome: a novel multi-faceted target for therapy. Trends in Biochemical Sciences, Elsevier, 2005, 30 (8), pp.469--78. ⟨hal-02262238⟩

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