Residues in the murine leukemia virus capsid that differentially govern resistance to mouse Fv1 and human Ref1 restrictions
Résumé
We identified new residues within a 101-amino-acid stretch of the murine leukemia virus capsid that differentially modulate resistance and susceptibility to the mouse Fv1 and human Ref1 genes. Among these residues, aspartate 92 and histidine 117 are both required for Fv1(b) resistance, whereas the latter is sufficient to confer Ref1 resistance.
Mots clés
Amino Acid Sequence Animals Capsid Proteins/chemistry/*genetics Cell Line DNA-(Apurinic or Apyrimidinic Site) Lyase/*genetics Genes
Molecular Molecular Sequence Data Proteins/*genetics Restriction Mapping Retroviridae Infections/*virology Sequence Alignment Transfection Tumor Virus Infections/*virology
Murine/*genetics Mice Models
Viral/genetics Humans Leukemia Virus