Letter by Pinet et al Regarding Article"Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury"

Abstract : We read the article written by Schulte et al 1 with great interest and appreciation. In this study, the authors performed a comparative analysis of circulating non-coding RNAs versus protein biomarkers to detect myocardial injury. Two cohorts of patients have been selected: patients undergoing transcoronary ablation of septal hypertrophy (TASH) with serial blood sampling (0-1-8-24h) and patients hospitalized for acute myocardial infarction (MI) with blood sampling (on admission, 1h and 3h). The non-coding RNAs were selected from literature or array screening for circulating RNAs. The authors treated all samples with heparinase to overcome the problem of heparin which interferes with quantification of RNAs by RT-qPCR 2. Their conclusion was that cardiac myosin-binding protein C was the most sensitive cardiac biomarker with miR-1 and miR-133a as promising candidates in patients with acute myocardial injury. However, results from the study should be interpreted with the following considerations for data on the lncRNA LIPCAR presented in this article. The authors refute a predominant cardiac origin of LIPCAR, because they did not detect modulation of LIPCAR during the short-time course of blood sampling (0-1-8-24h) of TASH patients. They hypothesize that its rise in plasma may be explained by a release of mitochondria from blood cells rather than cardiac injury. We disagree with the authors for a number of points.
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Submitted on : Friday, August 2, 2019 - 9:31:47 AM
Last modification on : Monday, August 5, 2019 - 10:50:39 AM

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Florence Pinet, Christophe Bauters, Christian Bär, Thomas Thum. Letter by Pinet et al Regarding Article"Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury". Circulation Research, American Heart Association, 2019, 125 (4), pp.e20-e21. ⟨10.1161/CIRCRESAHA.119.315530⟩. ⟨hal-02262184⟩

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