Variable influenza vaccine effectiveness by subtype: a 693 systematic review and meta-analysis of test-negative design studies, Lancet Infect, vol.694 ,
, , vol.16, pp.942-951, 2016.
H3N2 Mismatch of 2014-15 Northern Hemisphere Influenza 696 Vaccines and Head-to-head Comparison between Human and Ferret Antisera 697 derived, Antigenic Maps. Sci Rep, vol.5, p.15279, 2015. ,
Early estimates of seasonal influenza vaccine effectiveness-699 ,
, United States, MMWR Morb Mortal Wkly Rep, vol.16, issue.1, pp.10-15, 2015.
,
, Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift 703 during the 2014-2015 Influenza Season, Cell Rep, vol.12, pp.1-6, 2015.
Comparing influenza vaccine efficacy against mismatched 705 and matched strains: a systematic review and meta-analysis, BMC Medicine, vol.706, p.153, 2013. ,
Prior H1N1 influenza infection and susceptibility of Cleveland 708 ,
, Family Study participants during the H2N2 pandemic of 1957: an experiment of 709 nature, J Infect Dis, vol.193, pp.49-53, 2006.
Recovery from severe H7N9 disease is associated with diverse 711 response mechanisms dominated by CD8? T cells, Nat Commun, vol.6, p.6833, 2015. ,
Cellular immune correlates of protection against symptomatic 714 pandemic influenza, Nat Med, vol.19, pp.1305-1312, 2013. ,
Preexisting influenza-specific CD4+ T cells correlate with 716 disease protection against influenza challenge in humans, Nat Med, vol.18, pp.274-280, 2012. ,
Natural T Cell-mediated Protection against Seasonal and 719 ,
, Pandemic Influenza. Results of the Flu Watch Cohort Study, Am J Respir Crit, vol.720
, Care Med, vol.191, pp.1422-1431, 2015.
Evolution of the 722 nucleoprotein gene of influenza A virus, J Virol, vol.64, issue.4, pp.1487-1497, 1990. ,
Positive 724 ,
, Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by 725 a Comparative Analysis of Human and Swine Viral Lineages, J Virol, vol.89, pp.11275-726, 2015.
MVA vectors expressing conserved influenza proteins protect 728 mice against lethal challenge with H5N1, H9N2 and H7N1 viruses, PLoS One. 729, vol.11, issue.2, p.88340, 2014. ,
Systematic identification of immunodominant CD8+ T-cell 731 responses to influenza A virus in HLA-A2 individuals, Proc Natl Acad Sci, vol.108, pp.9178-9183, 2011. ,
Broadly neutralizing antiviral responses induced by a single-765 molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope 766 nanoparticles, Sci. Rep, vol.7, 2017. ,
Enhancing immunogenicity and transmission-blocking activity of 768 malaria vaccines by fusing Pfs25 to IMX313 multimerization technology, Sci 769 Rep, vol.6, p.18848, 2016. ,
A virus obtained from influenza 771 patients, Lancet, vol.222, pp.66-68, 1933. ,
Structural studies of 773 influenza virus RNPs by electron microscopy indicate molecular contortions 774 within NP supra-structures, J Struct Biol, vol.197, pp.294-307, 2017. ,
The mechanism by which influenza A virus 776 nucleoprotein forms oligomers and binds RNA, Nature, vol.21, issue.7122, pp.1078-82 ,
, Epub, 2006.
Cutting Edge: Generation of Splenic CD8+ and CD8? Dendritic 779 ,
, Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures, J 780 Immunol, vol.1, issue.11, pp.6592-6597, 2005.
Potent CD8+ T-cell immunogenicity in humans of a novel 785 heterosubtypic influenza A vaccine, MVA-NP+M1, Clin Infect Dis, vol.1, issue.1, pp.1-7, 2011. ,
Cell-mediated 788 protection in influenza infection, Emerg Infect Dis, vol.12, pp.48-54, 2006. ,
Advances in the development of universal influenza vaccines. 790 Influenza Other Respir Viruses, vol.7, pp.750-758, 2013. ,
Universal influenza virus vaccines and 792 therapeutic antibodies, Clin Microbiol Infect, vol.23, pp.222-228, 2017. ,
Prevention and control of influenza with vaccines: 794 recommendations of the Advisory Committee on Immunization Practices (ACIP), MMWR Recomm Rep, vol.59, issue.8, pp.1-62, 2010. ,
Central European Vaccination Advisory Group (CEVAG) 797 guidance statement on recommendations for influenza vaccination in children, BMC Infect Dis, vol.798, p.168, 2010. ,
Vaccination against human influenza A/H3N2 virus prevents 800 the induction of heterosubtypic immunity against lethal infection with avian 801 influenza A/H5N1 virus, PLoS One, vol.4, p.5538, 2009. ,
Heterologous protection against influenza by injection of DNA 803 encoding a viral protein, Science, vol.259, pp.1745-1749, 1993. ,
Protective CD4+ and CD8+ T cells against influenza virus 805 induced by vaccination with nucleoprotein DNA, J Virol, vol.72, pp.5648-5653, 1998. ,
Dose dependence of CTL precursor frequency induced by a DNA 807 vaccine and correlation with protective immunity against influenza virus 808 challenge, J. Immunol, vol.162, pp.4163-4170, 1999. ,
DNA Vaccine Expressing Conserved Influenza Virus Proteins 810 ,
, Protective Against H5N1 Challenge Infection in Mice, Emerg Infect Dis, vol.8, pp.796-811, 2002.
Cross-protective immunity to influenza A viruses. Differences were assessed by 1-way ANOVA followed by Tukey's Multiple 923 comparison test with 95% confidence intervals; p<0.05 is considered significant 924 (****p<0.0001) or by two-way ANOVA followed by a Dunnett's multiple 925 comparison test ,