FTO controls reversible m6Am RNA methylation during snRNA biogenesis

Jan Mauer , Miriam Sindelar , Vladimir Despic , Théo Guez (1) , Benjamin Hawley , Jean-Jacques Vasseur (1) , Andrea Rentmeister , Steven S Gross , Livio Pellizzoni (2) , Françoise Debart (1) , Hani Goodarzi , Samie R Jaffrey

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 University of Pennsylvania

Mots clés: STRUCTURAL BASIS; PRE-MESSENGER-RNAS; FAT MASS; U1 SNRNA; SMALL NUCLEAR-RNA; MATURATION; INHIBITION; IDENTIFICATION; N6-METHYLADENOSINE; CELL

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Chimie organique

Jan Mauer, Miriam Sindelar, Vladimir Despic, Théo Guez, Benjamin Hawley, et al.. FTO controls reversible m6Am RNA methylation during snRNA biogenesis. Nature Chemical Biology, 2019, 15 (4), pp.340-347. ⟨10.1038/s41589-019-0231-8⟩. ⟨hal-02197144⟩