Molecular and cellular basis of T cell lineage commitment - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Seminars in Immunology Année : 2010

Molecular and cellular basis of T cell lineage commitment

R. Vicente
  • Fonction : Auteur
L. Swainson
  • Fonction : Auteur
S. Marty-Gres
  • Fonction : Auteur
S. C. de Barros
  • Fonction : Auteur
S. Kinet
V. S. Zimmermann

Résumé

The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented.

Dates et versions

hal-02193631 , version 1 (24-07-2019)

Identifiants

Citer

R. Vicente, L. Swainson, S. Marty-Gres, S. C. de Barros, S. Kinet, et al.. Molecular and cellular basis of T cell lineage commitment. Seminars in Immunology, 2010, 22 (5), pp.270--5. ⟨10.1016/j.smim.2010.06.001⟩. ⟨hal-02193631⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More