Lymphotoxin alpha stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts

F. Calmon-Hamaty , B. Combe , M. Hahne (1) , J. Morel

1 IGMM - Institut de Génétique Moléculaire de Montpellier

Mots clés: Arthritis; Type II/metabolism Synovial Fluid/*cytology/drug effects p38 Mitogen-Activated Protein Kinases/metabolism; Type I/metabolism Receptors; Tumor Necrosis Factor; Tumor Necrosis Factor Receptors; Rheumatoid/*pathology Cell Nucleus/drug effects/metabolism Cell Proliferation/drug effects Cytokines/*secretion Enzyme Activation/drug effects Extracellular Signal-Regulated MAP Kinases/metabolism Fibroblasts/drug effects/enzymology/pathology/*secretion Humans Immunoglobulin G/pharmacology Inflammation Mediators/*metabolism Lymphotoxin-alpha/*pharmacology Matrix Metalloproteinase 3/secretion NF-kappa B/metabolism Protein Kinase Inhibitors/pharmacology Protein Transport/drug effects Proto-Oncogene Proteins c-akt/metabolism Receptors; Member 14/metabolism Receptors

Domaines: Biochimie, Biologie Moléculaire

F. Calmon-Hamaty, B. Combe, M. Hahne, J. Morel. Lymphotoxin alpha stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts. Cytokine, 2011, 53 (2), pp.207--14. ⟨10.1016/j.cyto.2010.10.010⟩. ⟨hal-02193484⟩