Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows

Anouchka Plan Sangnier (1, 2) , Romain Aufaure (1) , Soshan Cheong (3, 4) , Laurence Motte (1) , Bruno Palpant (5) , Richard Tilley (3, 4) , Erwann Guenin (6) , Claire Wilhelm (2) , Yoann Lalatonne (6, 1)

1 LVTS (UMR_S_1148 / U1148) - Laboratoire de Recherche Vasculaire Translationnelle
2 MSC - Matière et Systèmes Complexes
3 UNSW School of Chemistry [Sydney]
4 UNSW - Mark Wainwright Analytical Centre [Sydney]
5 LPQM - Laboratoire de Photonique Quantique et Moléculaire
6 CSPBAT - Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques

Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene glycol-functionalized bisphosphonates. The original structure shifted the optical absorption to infrared, revealing very efficient photothermal properties within the 2nd biological transparency window and leading to cancer cell necrosis at moderate intracellular doses and low (safe) laser power.

Domaines: Chimie

Anouchka Plan Sangnier, Romain Aufaure, Soshan Cheong, Laurence Motte, Bruno Palpant, et al.. Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows. Chemical Communications, 2019, 55 (28), pp.4055-4058. ⟨10.1039/C8CC09476D⟩. ⟨hal-02189487⟩