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Communication Dans Un Congrès Année : 2019

Discrimination between primary low and high grade tumor and secondary metastasis tumor from deep-UV to NIR

Résumé

Among Central Nervous System (CNS) tumors, diffuse glioma are the most infiltrating and malignant tumors. According to the World Health Organization (WHO), they are classified into different grades, referring to their pathological class and histological properties. To treat glioma tumors, many methods have been proposed, still the standard one remains the maximal safe total resection. During the operation, many difficulties obstruct the surgeon to identify the infiltrated areas, which contains diffuse tumors cells, around the solid area of the tumor, overlapping the healthy areas, and presenting the same visual appearances. If not totally removed, these infiltrating zones can increase the risk of recurrence and affects the survival rate of patient. To overcome this problem, we develop a multimodal two-photon endomicroscope, based on the endogenous fluorescence of brain tissues, to assist the surgeon during the surgery. The tool will provide him information on the infiltrated areas and their histological nature. In this paper, we tried to discriminate between metastasis, low grade and high grade glioma from healthy fresh tissues, presenting a multimodal study using deep ultraviolet, visible and near infrared excitation to acquire spectral measurements, Fluorescence Lifetime Imaging (FLIM) and Two-Photon Emission Fluorescence (TPEF) imaging. We compared also our TPEF and FLIM images to the histological images.
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Dates et versions

hal-02187918 , version 1 (18-07-2019)

Identifiants

Citer

Hussein Mehidine, Frederic Jamme, Audrey Chalumeau, Fanny Poulon, Pascale Varlet, et al.. Discrimination between primary low and high grade tumor and secondary metastasis tumor from deep-UV to NIR. SPIE BIOS 2019, Feb 2019, San Francisco, United States. pp.1087109, ⟨10.1117/12.2506766⟩. ⟨hal-02187918⟩
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