Stereoselective Synthesis of Fluorinated 1,3- cis -Diaminocyclopentanes

Morgane Pasco (1) , Roba Moumné (2) , Thomas Lecourt (1) , Laurent Micouin (3)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 SSFMB - Synthèse, Structure et Fonction de Molécules Bioactives
3 SSMIP - Synthèse et structure de molécules d'interet pharmacologique

Several fluorinated 1,3-diaminocyclopentanes, previously reported to be useful RNA structural probes, can be prepared in a diastereoselective manner from a single bicyclic hydrazine precursor, in 3 to 9 steps.

Domaines: Chimie organique

Morgane Pasco, Roba Moumné, Thomas Lecourt, Laurent Micouin. Stereoselective Synthesis of Fluorinated 1,3- cis -Diaminocyclopentanes. Journal of Organic Chemistry, 2011, 76 (12), pp.5137-5142. ⟨10.1021/jo2001512⟩. ⟨hal-02186896⟩