Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands

Paulina Gonzalez (1) , Karolina Bossak-Ahmad (2) , Bertrand Vileno (3) , Nina E Wezynfeld (1) , Youssef El Khoury (4) , Petra Hellwig (5) , Christelle Hureau (6) , Wojciech Bal (7) , Peter Faller (1)

1 Institut de Chimie de Strasbourg
2 Institute of Biochemistry & Biophysics - Polish Academy of Science
3 Institut de Chimie de Strasbourg
4 Laboratoire de Bioélectrochimie et Spectroscopie
5 USIAS - Institut d’Etudes Avancées de l’Université de Strasbourg - Institute for Advanced Study
6 LCC - Laboratoire de chimie de coordination
7 Institute of Biochemistry & Biophysics

Cu(II) forms well-known and stable complexes with peptides having histidine at position 2 (Xxx-His) or 3 (Xxx-Zzz-His). Their properties differ considerably due to the histidine positioning. Here we report that in the hybrid motif Xxx-His-His, the Cu(II)-complexes can be switched between the Xxx-His and the Xxx-Zzz-His coordination modes by addition of external ligands.

Domaines: Chimie; Chimie de coordination; Chimie inorganique; Biochimie, Biologie Moléculaire

Paulina Gonzalez, Karolina Bossak-Ahmad, Bertrand Vileno, Nina E Wezynfeld, Youssef El Khoury, et al.. Triggering Cu-coordination change in Cu( ii )-Ala-His-His by external ligands. Chemical Communications, 2019, 55 (56), pp.8110-8113. ⟨10.1039/c9cc03174j⟩. ⟨hal-02181666⟩