Skip to Main content Skip to Navigation
Journal articles

Vibrio tapetis Displays an Original Type IV Secretion System in Strains Pathogenic for Bivalve Molluscs

Abstract : The Brown Ring Disease (BRD) caused high mortality rates since 1986 in the Manila clam introduced and cultured in Western Europe from the 1970s. The causative agent of BRD is a Gram-Negative bacterium, , which is also pathogenic to fish. Here we report the first assembly of the complete genome of CECT4600, together with the genome sequences of 16 additional strains isolated across a broad host and geographic range. Our extensive genome dataset allowed us to describe the pathogen pan- and core genomes and to identify putative virulence factors. The core genome consists of 3,352 genes, including multiple potential virulence factors represented by haemolysins, transcriptional regulators, Type I restriction modification system, GGDEF domain proteins, several conjugative plasmids, and a Type IV secretion system. Future research on the coevolutionary arms race between virulence factors and host resistance mechanisms will improve our understanding of how pathogenicity develops in this emerging pathogen.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02177600
Contributor : Laurent Jonchère <>
Submitted on : Friday, July 12, 2019 - 2:06:49 PM
Last modification on : Friday, September 11, 2020 - 3:17:59 AM

File

pdf
Publisher files allowed on an open archive

Identifiers

Citation

Graciela M. Dias, Adeline Bidault, Patrick Le Chevalier, Gwenaëlle Choquet, Clio Der Sarkissian, et al.. Vibrio tapetis Displays an Original Type IV Secretion System in Strains Pathogenic for Bivalve Molluscs. Frontiers in Microbiology, Frontiers Media, 2018, 9, pp.227. ⟨10.3389/fmicb.2018.00227⟩. ⟨hal-02177600⟩

Share

Metrics

Record views

262

Files downloads

457