The Aryl Hydrocarbon Receptor, More than a Xenobiotic-Interacting Protein

Pedro M. Fernandez Salguero , Xavier Coumoul (1, 2) , Robert Barouki (1, 2)

1 U747 - Pharmacologie, toxicologie et signalisation cellulaire
2 UPD5 - Université Paris Descartes - Paris 5

The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a major issue in basic and clinical research, an increasing number of investigators are turning their efforts to try to understand the physiology of the AhR under normal cellular conditions. This is an exciting area that covers cell proliferation and differentiation, endogenous mechanisms of activation, gene regulation, tumor development and cell motility and migration, among others. In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes.

Mots clés: dissemin

Domaines: Sciences du Vivant [q-bio]

Pedro M. Fernandez Salguero, Xavier Coumoul, Robert Barouki. The Aryl Hydrocarbon Receptor, More than a Xenobiotic-Interacting Protein. FEBS Letters, 2007, 581 (19), pp.3608-3615. ⟨10.1016/j.febslet.2007.03.046⟩. ⟨hal-02175734⟩