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A new formulation for blood substitues

Abstract : The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH-CH-C4H9 with a biocompatible hy-drogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17-CH2-CH = CH-C4H9 was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications.
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Marie-Christine Cecutti, Anne Novelli, Isabelle Rico-Lattes, Armand Lattes. A new formulation for blood substitues. Journal of Dispersion Science and Technology, Taylor & Francis, 2007, 11 (2), pp.115-123. ⟨10.1080/01932699008943243⟩. ⟨hal-02168142⟩



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