, Our model need to be further tested through in-depth qualitative studies to better understand the condition of success of those user-driven projects on academic performances, particular, a focus on how managing those project would be useful for scholars and practitioners

, Furthermore, we particularly focus on industry partner in the ecosystem. The role of State, NonGovernmental Organisations and university offices also need to be further assess, vol.6

B. Abbott and . Alison, The Quiet Revolutionary: How the Co-Discovery of CRISPR Explosively Changed Emmanuelle Charpentier's Life, Nature, vol.532, issue.7600, pp.432-466, 2016.

M. Agogué, Modéliser l'effet Des Biais Cognitifs Sur Les Dynamiques Industrielles : Innovation Orpheline et Architecte de l'inconnu, 2012.

A. K. Agrawal and R. Henderson, Exploring Knowledge Transfer from MIT, Advances in Strategic Management, vol.26, p.26033, 1997.

D. Antonioli, A. Marzucchi, and M. Savona, Pain Shared, Pain Halved? Cooperation as a Coping Strategy for Innovation Barriers, Journal of Technology Transfer, vol.42, issue.4, pp.841-64, 2017.

P. Azoulay, D. Waverly, and S. Toby, The Impact of Academic Patenting on the Rate, Quality and Direction of (Public) Research Output, Journal of Industrial Economics, vol.57, issue.4, pp.637-76, 2009.

Y. Baba, N. Shichijo, and S. R. Sedita, How Do Collaborations with Universities Affect Firms' Innovative Performance? The Role of 'Pasteur Scientists' in the Advanced Materials Field, Research Policy, vol.38, issue.5, pp.756-64, 2009.

,

A. Banal-estañol, M. Jofre-bonet, and C. Lawson, The Double-Edged Sword of Industry Collaboration: Evidence from Engineering Academics in the UK, Research Policy, vol.44, issue.6, pp.1160-75, 2015.

D. Blumenthal, N. Causino, E. Campbell, and K. Louis, Relationships between Academic Institutions and Industry in the Life Sciences -An Industry Survey, New England Journal of Medicine, vol.334, issue.6, pp.368-74, 1996.

,

S. Breschi, F. Lissoni, and F. Montobbio, University Patenting and Scientific Productivity: A Quantitative Study of Italian Academic Inventors, European Management Review, vol.5, issue.2, pp.91-109, 2008.

V. Bush, Science, the Endless Frontier; a Report to the President on a Program for Postwar Scientific Research, 1945.

J. Calvert, What's Special about Basic Research, Technology & Human Values, vol.31, issue.2, pp.199-220, 2006.

E. G. Carayannis and D. F. Campbell, Mode 3 Knowledge Production in Quadruple Helix Innovation Systems, SpringerBriefs in Business, vol.7, 2012.

, Les Systèmes d'innovation de La Quadruple et de La Quintuple Hélice, Innovations, vol.54, issue.3, p.173, 2017.

H. Chesbrough and R. S. Rosenbloom, The Role of the Business Model in Capturing Value from Innovation : Evidence from Xerox Corporation ' s Technology Spin-off Companies, Industrial and Corporate Change, vol.11, issue.3, pp.529-55, 2002.

,

W. M. Cohen, Economic Security for a Better World, Indian Journal of Labour Economics, vol.47, issue.3, pp.601-608, 2004.

W. M. Cohen, J. Richard-r-nelson, and . Walsh, Links and Impacts: The Influence of Public Research on Industrial R and D, Management Science, vol.48, issue.1, pp.1-23, 2002.

D. Comin, G. Licht, M. Pellens, and T. Schubert, Do Companies Benefit from Public Research Organizations ? The Impact of the Fraunhofer Society in Germany Papers in Innovation Studies Do Companies Benefit from Public Research Organizations ? The Impact of the Fraunhofer Society in Germany, Innovation Studies, vol.7, 2018.

C. Comptes and . Des, Rapport Particulier Sur La Valorisation de La Recherche Civile Du CEA, 2018.

R. Crescenzi, A. Filippetti, and S. Iammarino, Academic Inventors: Collaboration and Proximity with Industry, Journal of Technology Transfer, vol.42, issue.4, pp.730-62, 2017.

J. Deaut, C. Le, and . Procaccia, Les Enjeux Économiques, Environnementaux, Sanitaires et Éthiques Des Biotechnologies à La Lumière Des Nouvelles Pistes de Recherche, 2017.

P. Debré, Louis Pasteur, 1993.

K. J. Egelie, D. Gregory, S. P. Graff, B. Strand, and . Johansen, The Emerging Patent Landscape of CRISPR -Cas Gene Editing Technology, Nature Publishing Group, vol.34, issue.10, pp.1025-1056, 2016.

H. Etzkowitz and L. Leydesdorff, The Dynamics of Innovation: From National Systems and 'Mode 2' to a Triple Helix of University-Industry-Government Relations, Research Policy, vol.29, issue.2, pp.55-59, 2000.

K. R. Fabrizio and A. D. Minin, Commercializing the Laboratory: Faculty Patenting and the Open Science Environment, Research Policy, vol.37, issue.5, pp.914-945, 2008.

,

V. Galán-muros and C. Plewa, What Drives and Inhibits UniversityBusiness Cooperation in Europe? A Comprehensive Assessement, R&D Management, vol.46, issue.2, pp.369-82, 2016.

M. Gibbons, C. Limoges, H. Nowotny, S. Schwartzman, and P. Scott, The New Production of Knowledge, 1994.

T. Gillier, G. Piat, B. Roussel, and P. Truchot, Managing Innovation Fields in a Cross-Industry Exploratory Partnership with C-K Design Theory, Journal of Product Innovation Management, vol.27, issue.6, pp.883-96, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00586603

B. Godin, The Linear Model of Innovation, the Historial Construction of an Analytical Framework, Technology & Human Values, vol.31, issue.6, pp.639-67, 2006.

,

A. P. Goldstein and V. Narayanamurti, Simultaneous Pursuit of Discovery and Invention in the US Department of Energy, Research Policy, vol.47, issue.8, pp.1505-1517, 2018.

,

M. Guerrero, J. A. Cunningham, and D. Urbano, Economic Impact of Entrepreneurial Universities' Activities: An Exploratory Study of the United Kingdom, Research Policy, vol.44, issue.3, pp.748-64, 2015.

M. Gulbrandsen and J. C. Smeby, Industry Funding and University Professors' Research Performance, Research Policy, vol.34, issue.6, pp.932-50, 2005.

,

A. Hatchuel, P. L. Masson, and B. Weil, Teaching Innovative Design Reasoning: How Concept-knowledge Theory Can Help Overcome Fixation Effects, AI EDAM, vol.25, issue.1, pp.77-92, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00660245

A. Hatchuel, Y. Reich, P. L. Masson, B. Weil, and A. O. Kazakçi, Beyond Models and Decisions : Situating Design Through Generative Functions, ICED13: 19th International Conference on Engineering Design, pp.1-10, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01485144

A. Hatchuel and B. Weil, A New Approach of Innovative Design: An Introduction to C-K Theory, International Conference on Engineering Design ICED 03, pp.1-15, 2003.

, CK Design Theory: An Advanced Formulation, Research in Engineering Design, vol.19, issue.4, pp.181-92, 2009.

M. ;. Jinek, ;. Krzysztof, I. ;. Chylinski, M. Fonfara, and J. Hauer,

E. Doudna and . Charpentier, A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity, Science, issue.337, pp.816-837, 2012.

,

D. Kanama and K. Nishikawa, What Type of Obstacles in Innovation Activities Make Firms Access University Knowledge? An Empirical Study of the Use of University Knowledge on Innovation Outcomes, Journal of Technology Transfer, vol.42, issue.1, pp.141-57, 2017.

S. Kaplan and M. Tripsas, Thinking about Technology: Applying a Cognitive Lens to Technical Change, Research Policy, vol.37, issue.5, pp.790-805, 2008.

,

K. Chen, P. Milena, L. Aknin, D. Lagadec, P. L. Laousse et al., Designing the Missing Link between Science and Industry: Organizing Partnership Based on Dual Generativity, 21st International Conference on Engineering Design, pp.307-323, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01619988

S. J. Kline and N. Rosenberg, An Overview of Innovation, 1986.

. Krawczyk-stuss, A. Ma?gorzata, B. Ostrowska, J. ?api?ska, E. Nowak et al., Evaluation of Shear Bond Strength of the Composite to Biodentine with Different Adhesive Systems, Dental and Medical Problems, vol.52, issue.4, pp.434-473, 2015.

E. S. Lander, Perspective The Heroes of CRISPR, Cell, vol.164, issue.1-2, pp.18-28, 2015.

B. Looy, J. Van, K. Callaert, and . Debackere, Publication and Patent Behavior of Academic Researchers: Conflicting, Reinforcing or Merely Co-Existing?, Research Policy, vol.35, issue.4, pp.596-608, 2006.

C. Martínez, J. M. Azagra-caro, and S. Maraut, Academic Inventors, Scientific Impact and the Institutionalisation of Pasteur's Quadrant in Spain, Industry and Innovation, vol.20, issue.5, pp.438-55, 2013.

P. Masson, B. Le, and . Weil, Fayol, Guillaume, Chevenard -La Science, l'industrie et l'exploratoire de l'inconnu : Logique et Gouvernance d'une Recherche Conceptive, Entreprises & Histoire, vol.83, issue.2, pp.79-107, 2016.

A. Mccabe, R. Parker, and S. Cox, The Ceiling to Coproduction in University-Industry Research Collaboration, Higher Education Research & Development, vol.35, issue.3, pp.560-74, 2016.

K. Miller, R. Mcadam, and M. Mcadam, A Systematic Literature Review of University Technology Transfer from a Quadruple Helix Perspective: Toward, issue.1, pp.7-24, 2016.

,

, An Exploration of the Role of Value Creation and Value Capture in University Technology Transfer Business Models: A Quadruple Helix Stakeholder Perspective, pp.1-47, 2018.

V. Narayanamurti, T. Odumosu, and L. Vinsel, RIP : The Basic / Applied Research Dichotomy, Issues in Science, vol.29, issue.2, pp.31-36, 2017.

. Oecd, Commercialising Public Research: New Trends and Strategies, 2013.

W. Ooms, C. Werker, C. J. Marjolein, H. Caniëls, . Van-den et al., Research Orientation and Agglomeration: Can Every Region Become a Silicon Valley, 2015.

M. Perkmann, V. Tartari, M. Mckelvey, E. Autio, A. Broström et al., Academic Engagement and Commercialisation: A Review of the Literature on University-Industry Relations, Research Policy, vol.42, issue.2, pp.423-465, 2013.

D. S. Siegel, A. N. David-waldman, and . Link, Assessing the Impact of Organizational Practices on the Productivity of University Technoloy Transfer Offices: An Exploratory Study, Research Policy, vol.32, issue.1, pp.27-48, 2003.

D. Stokes, Pasteur's Quadrant. Basic Science and Technological Innovation, 1997.

J. Sydow, Organizational Path Dependence: Opening the Black Box, Academy of Management Review, vol.34, issue.4, pp.689-709, 2009.

,

T. Taylor-aldridge and D. Audretsch, The Bayh-Dole Act and Scientist Entrepreneurship, Research Policy, vol.40, issue.8, pp.1058-67, 2011.

,

S. Thrane, S. Blaabjerg, and R. Møller, Innovative Path Dependence: Making Sense of Product and Service Innovation in Path Dependent Innovation Processes, Research Policy, vol.39, issue.7, pp.932-976, 2010.

,

R. J. Tijssen, Co-Authored Research Publications and Strategic Analysis of Public-Private Collaboration, Research Evaluation, vol.21, issue.3, pp.204-219, 2012.

, Anatomy of Use-Inspired Researchers: From Pasteur's Quadrant to Pasteur's Cube Model, Research Policy, vol.47, issue.9, pp.1626-1664, 2018.

,

A. Tylecote, Biotechnology as a New Techno-Economic Paradigm That Will Help Drive the World Economy and Mitigate Climate Change, Research Policy, pp.1-11, 2018.

E. Wit-de-vries, W. A. De, . Dolfsma, J. Henny, M. P. Van-der-windt et al., Knowledge Transfer in University-industry Research Partnerships: A Review, Journal of Technology Transfer, pp.1-20, 2018.

L. G. Zucker and M. R. Darby, Star Scientists and Institutional Transformation: Patterns of Invention and Innovation in the Formation of the Biotechnology Industry, Proceedings of the National Academy of Sciences, vol.93, issue.23, pp.12709-12725, 1996.

,