Electrochemical detection of nitric oxide and S-nitrosothiols in biological systems: past, present & future

Fethi Bedioui (1) , Abdulghani Ismail (1, 2) , Sophie Griveau (1)

1 UTCBS - UM 4 (UMR 8258 / U1022) - Unité de Technologies Chimiques et Biologiques pour la Santé
2 SYMMES - SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé

Electrochemical detection of nitric oxide using different electrode materials and strategies exploded after the discovery of nitric oxide as important biological messenger. S-nitrosothiols (RSNOs), which result from interaction of NO with peptides and proteins, were shown to be important pools of NO that interfere in different physiological and pathological conditions. This lead to development of several decomposition methods to detect RSNOs electrochemically. This mini-review summarizes the beginning and the current investigations in electrochemical methods to detect NO and RSNOs. Indeed, it describes the latest trends to detect NO and RSNO using microfluidic technologies coupled to electrochemistry and discuss the future of NO and RSNOs detection.

Mots clés: nanoparticles; microfluidics; nitric oxide; electrochemical detection; ultramicroelectrodes; nanomaterials; S-nitrosothiols; microchip capillary electrophoresis

Domaines: Chimie analytique; Biochimie [q-bio.BM]

Fethi Bedioui, Abdulghani Ismail, Sophie Griveau. Electrochemical detection of nitric oxide and S-nitrosothiols in biological systems: past, present & future. Current Opinion in Electrochemistry, 2018, 12, pp.42-50. ⟨10.1016/j.coelec.2018.04.014⟩. ⟨hal-02159765⟩