P. J. Baugher and L. Krishnamoorthy, Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells, Breast Cancer Research, vol.7, pp.965-974, 2005.

I. Boutet and D. Moraga, Characterisation of reproduction-specific genes in a marine bivalve mollusc: influence of maturation stage and sex on mRNA expression, Gene, vol.407, pp.130-138, 2008.

D. Bucke, A. D. Vethaak, T. Lang, and S. Mellergaard, Common diseases and parasites of fish in the North Atlantic: Training guide for identification. ICES Techniques in Marine Environmental Sciences, vol.27, p.19, 1996.

S. A. Bustin and V. Benes, The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments, Clinical Chemistry, vol.55, pp.611-633, 2009.

C. M. Ciocan and E. Cubero-leon, Identification of reproduction-specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis, PLoS One, vol.6, issue.7, p.22326, 2011.

K. A. Cole and D. B. Krizman, The genetics of cancer -A 3D model, Nature Genetics, vol.21, issue.1, pp.38-41, 1999.

J. A. Craft and J. A. Gilbert, Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue specific expression patterns, PLoS ONE, vol.5, p.8875, 2010.

W. J. Cui and Y. Liu, Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway, Acta Pharmacologica Sinica, vol.31, pp.725-732, 2010.

K. M. Draheim and H. B. Chen, ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4, Oncogene, vol.29, pp.5032-5047, 2010.

F. A. Du-corbier and G. D. Stentiford, Isolation of the retinoblastoma cDNA from the marine flatfish dab (Limanda limanda) and evidence of mutational alterations in liver tumors, Environmental Science and Technology, vol.39, issue.24, pp.9785-9790, 2005.

J. E. Eckel-passow and D. J. Serie, ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma, BiomedCentral Urology, vol.14, p.14, 2014.

S. W. Feist and T. Lang, Biological effects of contaminants: use of liver pathology of the European flatfish dab (Limanda limanda L.) and flounder (Platichthys flesus L.) for monitoring, p.42, 2004.

R. A. Garcia-fernandez and P. Garcia-fernandez, Combined loss of p21 (waf1/cip1) and p27 (kip1) enhances tumorigenesis in mice, Laboratory Investigation, vol.91, pp.1634-1642, 2011.

J. W. Gillespie and M. Ahram, The role of tissue microdissection in cancer research, Nature Genetics, vol.43, pp.828-829, 2001.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using realtime quantitative PCR and the 2(T)(-Delta Delta C) method, Methods, vol.25, pp.402-408, 2001.

J. A. Luckenbach and D. B. Iliev, Identification of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, Oncohynchus kisutch, Reproductive Biology and Endocrinology, vol.6, pp.2-18, 2008.

B. P. Lyons and G. D. Stentiford, DNA adduct analysis and histopathological biomarkers in European flounder (Platichthys flesus) sampled from UK estuaries, Mutation Research -Fundamental and Molecular Mechanisms of Mutagenesis, vol.552, issue.1-2, pp.177-186, 2004.

B. P. Lyons and J. P. Bignell, Determining good environmental status under the Marine Strategy Framework Directive: Case study for descriptor 8 (chemical contaminants), Marine Environmental Research, 2015.

D. C. Malins and M. M. Krahn, Toxic-chemicals in marine sediment and biota from Mukilteo, Washington -relationships with hepatic neoplasms and other hepatic-lesions in, 1985.

S. B. Oldham and L. G. Lipson, Presence of calmodulin in parathyroid adenomas, Minerals and Electrolyte Metabolism, vol.7, pp.273-280, 1982.

A. Oppelt and E. M. Haugsten, PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1, Biochemical Journal, vol.461, pp.383-390, 2014.

S. Qi and M. O'hayre, Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3), Journal of Biological Chemistry, vol.289, pp.4743-4752, 2014.

J. M. Rotchell and F. A. Du-corbier, A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans, Comparative Biochemistry and Physiology -C Toxicology and Pharmacology, vol.149, issue.2, pp.134-140, 2009.

S. Sakai and C. Miyajima, Tribbles-related protein family members as regulators or substrates of the ubiquitin-proteasome system in cancer development, Current Cancer Drug Treatments, vol.16, pp.147-156, 2016.

M. Schaeck and W. Despiegelaere, Laser capture microdissection of intestinal tissue from sea bass larvae using an optimised RNA integrity assay and validated reference genes, Scientific Reports, vol.6, p.21092, 2016.

C. Simone and L. Bagella, Physical interaction between pRB and cdk9/cyclinT2 complex, Oncogene, vol.21, pp.4158-4165, 2002.

P. Sluka and L. O'donnell, Application of laser-capture microdissection to analysis of gene expression in the testis, Progress in Histochemistry and Cytochemistry, vol.42, issue.4, pp.173-201, 2008.

H. J. Small and J. Sturve, Laser-assisted microdissection: A new tool for aquatic molecular parasitology, Diseases of Aquatic Organisms, vol.82, issue.2, pp.151-156, 2008.

H. J. Small and T. D. Williams, Gene expression analyses of hepatocellular adenoma and hepatocellular carcinoma from the marine flatfish Limanda Limanda, Diseases of Aquatic Organisms, vol.88, issue.2, pp.127-141, 2010.

A. D. Southam and J. M. Easton, Metabolic changes in flatfish hepatic tumours revealed by NMR-based metabolomics and metabolic correlation networks, Journal of Proteome Research, vol.7, issue.12, pp.5277-5285, 2008.

G. D. Stentiford and M. Longshaw, Histopathological biomarkers in estuarine fish species for the assessment of biological effects of contaminants, Marine Environmental Research, vol.55, issue.2, pp.137-159, 2003.

G. D. Stentiford and M. R. Viant, Liver tumors in wild flatfish: A histopathological, proteomic, and metabolomic study, OMICS A Journal of Integrative Biology, vol.9, issue.3, pp.281-299, 2005.

G. D. Stentiford and J. P. Bignell, Site-specific disease profiles in fish and their use in environmental monitoring, Marine Ecology Progress Series, vol.381, pp.1-15, 2009.

G. D. Stentiford and J. P. Bignell, Effect of age on liver pathology and other diseases in flatfish: implications for assessment of marine ecological health status, Marine Ecology Progress Series, vol.411, pp.215-230, 2010.

H. M. Stern and L. I. Zon, Cancer genetics and drug discovery in the zebrafish, Nature Reviews Cancer, vol.3, issue.7, pp.533-539, 2003.

R. Urbatzka and S. Galante-oliveira, Tissue expression of PPAR-alpha isoforms in Scophthalmus maximus and transcriptional response of target genes in the heart after exposure to WY-14643, Fish Physiology and Biochemistry, vol.39, 2013.

A. D. Vethaak and T. Rheinallt, Fish disease as a monitor for marine pollution: the case of the North Sea, Reviews in Fish Biology and Fisheries, vol.2, issue.1, pp.1-32, 1992.

J. Vinas and F. Piferrer, Stage-specific gene expression during fish spermatogenesis as determined by laser-capture microdissection and quantitative-PCR in sea bass (Dicentrarchus labrax) gonads, Biology of Reproduction, vol.79, issue.4, pp.738-747, 2008.

D. G. Ward and W. Wei, Plasma proteome analysis reveals the geographical origin and liver tumor status of dab (Limanda limanda) from UK marine waters, Environmental Science & Technology, vol.40, pp.4031-4036, 2006.

A. Wiebring and H. Helmholz, Separation and analysis of different types of nematocysts from Cyanea capillata (L.) medusae, Hydrobiologia, vol.645, issue.1, pp.203-212, 2010.

T. Yokoyama and T. Nakamura, Tribbles in disease: signalling pathways important for cellular function and neoplastic transformation, Cancer Science, vol.102, pp.1115-1122, 2011.

M. F. Yuen and P. C. Wu, Expression of c-myc, c-fos, and c-jun in hepatocellular carcinoma, Cancer, vol.91, pp.106-112, 2001.

I. Zandvakili and A. K. Davis, Loss of RhoA exacerbates, rather than dampens, oncogenic K-ras induced lung adenoma formation in mice, PloS ONE, vol.10, p.127923, 2015.