Neurons and brain macrophages regulate connexin expression in cultured astrocytes.

Annette Koulakoff (1) , William Même (1) , Charles-Félix Calvo , Pascal Ezan , Nathalie Rouach , Christian Giaume

1 INSERM U114 - Collège de France - Chaire Neuropharmacologie

Neurons and brain macrophages (BM), respectively, increase and inhibit gap junctional communication (GJC) and connexin expression in cultured astrocytes. Thus, in brain diseases and injuries, neuronal death associated with the BM activation may decrease GJC in astrocytes and therefore have a physiopathological relevance.

Domaines: Sciences du Vivant [q-bio]

Annette Koulakoff, William Même, Charles-Félix Calvo, Pascal Ezan, Nathalie Rouach, et al.. Neurons and brain macrophages regulate connexin expression in cultured astrocytes.. Cell Communication and Adhesion, 2003, 10 (4-6), pp.407-11. ⟨hal-02149146⟩