Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy

Céline Bourgier (1, 2, 3) , Jérôme Lacombe (2, 3) , Jérôme Solassol (2, 4, 3) , Alain Mangé (2, 3) , André Pèlegrin (2, 3) , Mahmut Ozsahin (5) , David Azria (2, 1, 3)

1 CRLC Val d'Aurelle-Paul Lamarque
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 UM - Université de Montpellier
4 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
5 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]

Radiation therapy undeniably enhances local control and thus improves overall survival in cancer patients. However, some long-term cancer survivors (less than 10%) develop severe late radio-induced toxicities altering their quality of life. Therefore, there is a need to identify patients who are sensitive to those toxicities and who could benefit from adapted care. In this review, we address all available techniques aiming to detect patients' hyper-radiosensitivity and present the scientific rationales these techniques are based on.

Mots clés: Predictive markers; Radiotherapy outcome

Domaines: Cancer; Hématologie

Céline Bourgier, Jérôme Lacombe, Jérôme Solassol, Alain Mangé, André Pèlegrin, et al.. Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy. Critical Reviews in Oncology/Hematology, 2015, 93 (3), pp.312-319. ⟨10.1016/j.critrevonc.2014.11.004⟩. ⟨hal-02148578⟩